Direct detection of candida albicans with a membrane based electrochemical impedance spectroscopy sensor

Dorota Kwasny, Sheida Esmail Tehrani, Catarina Almeida, Ida Schjødt, Maria Dimaki, Winnie Edith Svendsen*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Candidemia and invasive candidiasis is a cause of high mortality and morbidity rates among hospitalized patients worldwide. The occurrence of the infections increases due to the complexity of the patients and overuse of the antifungal therapy. The current Candida detection method includes blood culturing which is a lengthy procedure and thus delays the administration of the antifungal therapy. Even though the results are available after 48 h it is still the gold standard in pathogen detection in a hospital setting. In this work we present an electrochemical impedance sensor that is capable of detecting Candida albicans yeast. The yeast cells are captured on electrodes specifically functionalized with anti-Candida antibodies and detection is achieved by electrochemical impedance spectroscopy. The sensor allows for detection of the yeast cells at clinically relevant concentrations in less than 1 h.
    Original languageEnglish
    Article number2214
    JournalSensors
    Volume18
    Issue number7
    ISSN1424-8220
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Candida
    • Electrochemical impedance spectroscopy
    • Membrane based sensor

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