Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

Masood Hosseini; Henriette Kringelum; A. Murray; Janne Ejrnæs Tønder

Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

Masood Hosseini
, Henriette Kringelum
, A. Murray
, Janne Ejrnæs Tønder

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.

Original language	English
Journal	Organic Letters
Volume	8
Issue number	10
Pages (from-to)	2103-2106
ISSN	1523-7060
Publication status	Published - 2006

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title = "Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones",

abstract = "Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.",

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T1 - Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

AU - Hosseini, Masood

AU - Kringelum, Henriette

AU - Murray, A.

AU - Tønder, Janne Ejrnæs

PY - 2006

Y1 - 2006

N2 - Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.

AB - Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.

M3 - Journal article

SN - 1523-7060

VL - 8

SP - 2103

EP - 2106

JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

Abstract

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