Abstract
Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.
Original language | English |
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Journal | Organic Letters |
Volume | 8 |
Issue number | 10 |
Pages (from-to) | 2103-2106 |
ISSN | 1523-7060 |
Publication status | Published - 2006 |