Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

Masood Hosseini, Henriette Kringelum, A. Murray, Janne Ejrnæs Tønder

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.
Original languageEnglish
JournalOrganic Letters
Volume8
Issue number10
Pages (from-to)2103-2106
ISSN1523-7060
Publication statusPublished - 2006

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