TY - JOUR
T1 - Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca(2+)-Binding Motif
AU - Fernández-Pastor, Ignacio
AU - Ortiz-López, Francisco Javier
AU - Oves-Costales, Daniel
AU - Martín, Jesús
AU - Sánchez, Pilar
AU - Melguizo, Ángeles
AU - Reyes Gonzalez, Fernando
AU - Weber, Tilmann
AU - Genilloud, Olga
PY - 2024
Y1 - 2024
N2 - Genome analysis of strain Streptomyces sp. CA-278952 revealed a biosynthetic gene cluster encoding a putative lipopeptide with a sequence containing an Asp-Gly-Glu-Ala motif. We envisioned that this motif could mimic the canonical Asp-X-Asp-Gly sequence found in previously reported calcium-dependent lipopeptide antibiotics. Chemical investigation of the producing strain led to the discovery of three novel lipodepsipeptides, dilarmycins A–C. The calcium-dependent antibacterial activity of the new compounds was confirmed against the Gram-positive pathogens methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
AB - Genome analysis of strain Streptomyces sp. CA-278952 revealed a biosynthetic gene cluster encoding a putative lipopeptide with a sequence containing an Asp-Gly-Glu-Ala motif. We envisioned that this motif could mimic the canonical Asp-X-Asp-Gly sequence found in previously reported calcium-dependent lipopeptide antibiotics. Chemical investigation of the producing strain led to the discovery of three novel lipodepsipeptides, dilarmycins A–C. The calcium-dependent antibacterial activity of the new compounds was confirmed against the Gram-positive pathogens methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
U2 - 10.1021/acs.orglett.3c04195
DO - 10.1021/acs.orglett.3c04195
M3 - Journal article
C2 - 38329455
SN - 1523-7060
VL - 26
SP - 1343
EP - 1347
JO - Organic Letters
JF - Organic Letters
IS - 7
ER -