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Abstract
Bacterial small RNAs (sRNAs) are recognized as posttranscriptional regulators involved in the control of bacterial lifestyle and adaptation to stressful conditions. Although chemical stress due to the toxicity of precursor and product compounds is frequently encountered in microbial bioprocessing applications, the involvement of sRNAs in this process is not well understood. We have used RNA sequencing to map sRNA expression in E. coli under chemical stress and high cell density fermentation conditions with the aim of identifying sRNAs involved in the transcriptional response and those with potential roles in stress tolerance.
| Original language | English |
|---|---|
| Journal | B M C Genomics |
| Volume | 16 |
| Issue number | 1051 |
| Number of pages | 16 |
| ISSN | 1471-2164 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- sRNA
- RNA-seq
- Fermentation
- Chemical stress
- MicF
- RybB
- OmrB
- CyaR
- RyhB
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Dive into the research topics of 'Differential expression of small RNAs under chemical stress and fed-batch fermentation in E. coli'. Together they form a unique fingerprint.Projects
- 1 Finished
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BacTory: Biorefinery Training Platform: Bacterial Factories for Sustainable Chemical and Drug Production
Molin, S. (Project Manager), Nørholm, M. (Project Manager), Cavaleiro, M. (PhD Student), Machado, H. (PhD Student), Wendel, S. (PhD Student), van der Helm, E. (PhD Student), Bojanovic, K. (PhD Student), Vazquez Albacete, D. (Project Participant), D'Arrigo, I. (PhD Student), Li, S. (PhD Student), Yang, X. (PhD Student), Redl, S. M. A. (PhD Student), Pogrebnyakov, I. (PhD Student), Lehning, C. E. (PhD Student), Giubergia, S. (PhD Student), Calero Valdayo, P. M. (PhD Student) & Lohmann, R. (Project Manager)
01/10/2012 → 31/01/2017
Project: Research