Differential effects of strength training and testosterone treatment on soluble CD36 in aging men: Possible relation to changes in body composition

Dorte Glintborg, Louise L Christensen, Thue Kvorning, Rasmus Larsen, Kurt Højlund, Kim Brixen, David M Hougaard, Aase Handberg, Marianne Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose. We measured soluble CD36 (sCD36) and body composition to determine the effects of testosterone treatment (TT) and/or strength training (ST) on cardiovascular risk in men with low normal testosterone levels. Methods. Double-blinded, placebo-controlled study in 54 men aged 60-78 years with bioavailable testosterone <7.3 nmol/L and waist > 94 cm randomized to TT (gel, 50-100 mg/day, n = 20), placebo (n = 18) or ST (n = 16) for 6 months. Moreover, the ST group was randomized to TT (ST + TT, n = 7) or placebo (ST + placebo, n = 9) after 3 months. Outcomes. sCD36, total and regional fat mass were established by Dual X-ray absorptiometry and magnetic resonance imaging. Data are presented as median (quartiles). Kruskal-Wallis and Mann-Whitney tests were performed on delta values at 0, 3 and 6 months. Results. ST + placebo decreased sCD36 levels by 21% [from 0.80 (0.68-1.22) to 0.63 (0.51-0.73) rel. units] vs. TT and vs. placebo (p <0.05). ST + placebo did not change bioavailable testosterone and lean body mass. Fat mass measures significantly improved during ST + placebo, ST + TT, and TT vs. placebo. During ST + placebo, delta sCD36 was associated with delta total fat mass (r = 0.81) and delta central fat mass (r = 0.84). Conclusions. Compared to testosterone treatment, six months of strength training reduced sCD36 levels suggesting decreased cardiovascular risk, possibly due to a reduction in central fat mass.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume75
Issue number8
Pages (from-to)659-66
ISSN0036-5513
DOIs
Publication statusPublished - 2015

Keywords

  • DXA-scan
  • Relative hypogonadism
  • abdominal fat
  • biochemical marker
  • body fat distribution
  • magnetic resonance imaging (MRI)

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