Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys

Camilla Hoppe, Christian Mølgaard, Cathrine Dalum, Allan Vaag, Kim Fleischer Michaelsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background/Objectives: Milk increases both fasting insulin and insulin-like growth factor 1 (IGF-1), and thereby growth, in healthy prepubertal boys. It is, however, unknown which components in milk are responsible for milk’s growth-stimulating effect. Subjects/Methods: To get closer to the identification of which components in milk that stimulate growth, we have performed an intervention study with 57 eight-year-old boys in which we examined the effects of the two major milk protein fractions, whey and casein, and milk minerals (Ca and P) in a 2x2 factorial design on IGFs and glucose–insulin metabolism. The amounts of whey and casein were identical to the content in 1.5 l skim milk. The amounts of Ca and P were similar to 1.5 l skim milk in the high-mineral drinks, whereas the amounts of Ca and P were reduced in the low-mineral drinks. Results: There were no interactions between milk mineral groups (high, low) and milk protein groups (whey, casein). Serum IGF-1 increased by 15% (P
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume63
Issue number9
Pages (from-to)1076-1083
ISSN0954-3007
DOIs
Publication statusPublished - 2009

Keywords

  • Whey
  • Milk
  • IGF.1
  • Children
  • Insulin
  • Casein

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