Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3

results from a randomized 7-day supplementation study in prepubertal boys

Camilla Hoppe, Christian Mølgaard, Cathrine Dalum, Allan Vaag, Kim Fleischer Michaelsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background/Objectives: Milk increases both fasting insulin and insulin-like growth factor 1 (IGF-1), and thereby growth, in healthy prepubertal boys. It is, however, unknown which components in milk are responsible for milk’s growth-stimulating effect. Subjects/Methods: To get closer to the identification of which components in milk that stimulate growth, we have performed an intervention study with 57 eight-year-old boys in which we examined the effects of the two major milk protein fractions, whey and casein, and milk minerals (Ca and P) in a 2x2 factorial design on IGFs and glucose–insulin metabolism. The amounts of whey and casein were identical to the content in 1.5 l skim milk. The amounts of Ca and P were similar to 1.5 l skim milk in the high-mineral drinks, whereas the amounts of Ca and P were reduced in the low-mineral drinks. Results: There were no interactions between milk mineral groups (high, low) and milk protein groups (whey, casein). Serum IGF-1 increased by 15% (P
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume63
Issue number9
Pages (from-to)1076-1083
ISSN0954-3007
DOIs
Publication statusPublished - 2009

Keywords

  • Whey
  • Milk
  • IGF.1
  • Children
  • Insulin
  • Casein

Cite this

Hoppe, Camilla ; Mølgaard, Christian ; Dalum, Cathrine ; Vaag, Allan ; Michaelsen, Kim Fleischer. / Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3 : results from a randomized 7-day supplementation study in prepubertal boys. In: European Journal of Clinical Nutrition. 2009 ; Vol. 63, No. 9. pp. 1076-1083.
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Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3 : results from a randomized 7-day supplementation study in prepubertal boys. / Hoppe, Camilla ; Mølgaard, Christian; Dalum, Cathrine; Vaag, Allan; Michaelsen, Kim Fleischer.

In: European Journal of Clinical Nutrition, Vol. 63, No. 9, 2009, p. 1076-1083.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3

T2 - results from a randomized 7-day supplementation study in prepubertal boys

AU - Hoppe, Camilla

AU - Mølgaard, Christian

AU - Dalum, Cathrine

AU - Vaag, Allan

AU - Michaelsen, Kim Fleischer

PY - 2009

Y1 - 2009

N2 - Background/Objectives: Milk increases both fasting insulin and insulin-like growth factor 1 (IGF-1), and thereby growth, in healthy prepubertal boys. It is, however, unknown which components in milk are responsible for milk’s growth-stimulating effect. Subjects/Methods: To get closer to the identification of which components in milk that stimulate growth, we have performed an intervention study with 57 eight-year-old boys in which we examined the effects of the two major milk protein fractions, whey and casein, and milk minerals (Ca and P) in a 2x2 factorial design on IGFs and glucose–insulin metabolism. The amounts of whey and casein were identical to the content in 1.5 l skim milk. The amounts of Ca and P were similar to 1.5 l skim milk in the high-mineral drinks, whereas the amounts of Ca and P were reduced in the low-mineral drinks. Results: There were no interactions between milk mineral groups (high, low) and milk protein groups (whey, casein). Serum IGF-1 increased by 15% (P

AB - Background/Objectives: Milk increases both fasting insulin and insulin-like growth factor 1 (IGF-1), and thereby growth, in healthy prepubertal boys. It is, however, unknown which components in milk are responsible for milk’s growth-stimulating effect. Subjects/Methods: To get closer to the identification of which components in milk that stimulate growth, we have performed an intervention study with 57 eight-year-old boys in which we examined the effects of the two major milk protein fractions, whey and casein, and milk minerals (Ca and P) in a 2x2 factorial design on IGFs and glucose–insulin metabolism. The amounts of whey and casein were identical to the content in 1.5 l skim milk. The amounts of Ca and P were similar to 1.5 l skim milk in the high-mineral drinks, whereas the amounts of Ca and P were reduced in the low-mineral drinks. Results: There were no interactions between milk mineral groups (high, low) and milk protein groups (whey, casein). Serum IGF-1 increased by 15% (P

KW - Whey

KW - Milk

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KW - Children

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KW - Casein

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DO - 10.1038/ejcn.2009.34

M3 - Journal article

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