Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

Christian Hollensen; Gitte Persson; Liselotte Højgaard; Lena Specht; Rasmus Larsen

doi:10.1007/978-3-642-38079-2_16

Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

Christian Hollensen, Gitte Persson, Liselotte Højgaard, Lena Specht, Rasmus Larsen

Copenhagen University Hospital Herlev and Gentofte

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more suitable for setup and execution errors. In this study we use the GTV delineations made by 6 experienced clinicians to create delineation-specific dose plans. These dose plans are then used to calculate theoretic tumor control probabilities (TCP) differences between delineations. The results show that current margin recipes are inadequate for maintaining the same TCP despite manual delineation variation. New methods to account for delineation variation should be developed.

Original language	English
Title of host publication	Clinical Image-Based Procedures. From Planning to Intervention : International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers
Publisher	Springer
Publication date	2013
Pages	122-129
ISBN (Print)	978-3-642-38078-5
ISBN (Electronic)	978-3-642-38079-2
DOIs	https://doi.org/10.1007/978-3-642-38079-2_16
Publication status	Published - 2013
Event	15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012) : Workshop on Clinical Image-based Procedures (CLIP) - Nice, France Duration: 5 Oct 2012 → … http://miccai-clip.org/2012/

Workshop

Workshop	15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012) : Workshop on Clinical Image-based Procedures (CLIP)
Country/Territory	France
City	Nice
Period	05/10/2012 → …
Internet address	http://miccai-clip.org/2012/

Series	Lecture Notes in Computer Science
Volume	7761
ISSN	0302-9743

Keywords

Dose planning
Contouring observer variation
Lung tumor
Radiotherapy
Tumor control probability

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10.1007/978-3-642-38079-2_16

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Hollensen, C., Persson, G., Højgaard, L., Specht, L., & Larsen, R. (2013). Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. In Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers (pp. 122-129). Springer. https://doi.org/10.1007/978-3-642-38079-2_16

Hollensen, Christian ; Persson, Gitte ; Højgaard, Liselotte et al. / Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers. Springer, 2013. pp. 122-129 (Lecture Notes in Computer Science, Vol. 7761).

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abstract = "Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more suitable for setup and execution errors. In this study we use the GTV delineations made by 6 experienced clinicians to create delineation-specific dose plans. These dose plans are then used to calculate theoretic tumor control probabilities (TCP) differences between delineations. The results show that current margin recipes are inadequate for maintaining the same TCP despite manual delineation variation. New methods to account for delineation variation should be developed.",

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Hollensen, C, Persson, G, Højgaard, L, Specht, L & Larsen, R 2013, Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. in Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers. Springer, Lecture Notes in Computer Science, vol. 7761, pp. 122-129, 15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012) : Workshop on Clinical Image-based Procedures (CLIP), Nice, France, 05/10/2012. https://doi.org/10.1007/978-3-642-38079-2_16

Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. / Hollensen, Christian; Persson, Gitte; Højgaard, Liselotte et al.
Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers. Springer, 2013. p. 122-129 (Lecture Notes in Computer Science, Vol. 7761).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AB - Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more suitable for setup and execution errors. In this study we use the GTV delineations made by 6 experienced clinicians to create delineation-specific dose plans. These dose plans are then used to calculate theoretic tumor control probabilities (TCP) differences between delineations. The results show that current margin recipes are inadequate for maintaining the same TCP despite manual delineation variation. New methods to account for delineation variation should be developed.

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Hollensen C, Persson G, Højgaard L, Specht L, Larsen R. Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. In Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers. Springer. 2013. p. 122-129. (Lecture Notes in Computer Science, Vol. 7761). doi: 10.1007/978-3-642-38079-2_16

Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

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Workshop

Keywords

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