Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

Christian Hollensen, Gitte Persson, Liselotte Højgaard, Lena Specht, Rasmus Larsen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more suitable for setup and execution errors. In this study we use the GTV delineations made by 6 experienced clinicians to create delineation-specific dose plans. These dose plans are then used to calculate theoretic tumor control probabilities (TCP) differences between delineations. The results show that current margin recipes are inadequate for maintaining the same TCP despite manual delineation variation. New methods to account for delineation variation should be developed.
Original languageEnglish
Title of host publicationClinical Image-Based Procedures. From Planning to Intervention : International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers
PublisherSpringer
Publication date2013
Pages122-129
ISBN (Print)978-3-642-38078-5
ISBN (Electronic)978-3-642-38079-2
DOIs
Publication statusPublished - 2013
Event15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012) : Workshop on Clinical Image-based Procedures (CLIP) - Nice, France
Duration: 5 Oct 2012 → …
http://miccai-clip.org/2012/

Workshop

Workshop15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012) : Workshop on Clinical Image-based Procedures (CLIP)
CountryFrance
CityNice
Period05/10/2012 → …
Internet address
SeriesLecture Notes in Computer Science
Volume7761
ISSN0302-9743

Keywords

  • Dose planning
  • Contouring observer variation
  • Lung tumor
  • Radiotherapy
  • Tumor control probability

Cite this

Hollensen, C., Persson, G., Højgaard, L., Specht, L., & Larsen, R. (2013). Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. In Clinical Image-Based Procedures. From Planning to Intervention: International Workshop, CLIP 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers (pp. 122-129). Springer. Lecture Notes in Computer Science, Vol.. 7761 https://doi.org/10.1007/978-3-642-38079-2_16