Abstract
Background: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) has been ascribed potential anti-atherosclerotic properties and suggested to be an important nutrient explaining the protective effect on coronary heart disease provided by a Mediterranean diet. However, knowledge on the association between ALA intake and development of peripheral arterial disease (PAD) is lacking.
Purpose: The objective of this study was to investigate the association between ALA intake and development of incident PAD.
Methods: This prospective study was based on data from the Danish Diet, Cancer and Health cohort (n=57,053). This cohort of middle-aged men and women was established between 1993 and 1997 and has been followed onwards by record linkage with the Danish National Patient Register. Potential cases of PAD were identified and subsequently validated. Dietary intake of ALA was assessed using a validated food frequency questionnaire. Statistical analyses were performed using Cox proportional hazard regression allowing for separate baseline hazards among genders and adjusted for established risk factors for PAD.
Results: During a median of 13.6 years of follow-up, we identified 950 cases of PAD with complete information on covariates. The median energy-adjusted ALA intake was 1.76 g/d (95% central range: 0.94–3.28 g/d). In multivariable analyses, we observed a weak inverse U-shaped association between quintiles of energy-adjusted ALA intake and the risk of PAD. However, using the first quintile as reference the individual hazard ratios (HRs) for the second (HR: 1.08, 95% CI: 0.85–1.38), third (HR: 1.14, 95% CI: 0.91–1.45), fourth (HR: 1.10, 95% CI: 0.87–1.40) and fifth quintile (HR: 1.05, 95% CI: 0.83–1.34) were not statistically significant. Similar patterns were observed in gender-specific analyses.
Conclusion: This study does not suggest that dietary intake of ALA is appreciably associated with the risk of PAD.
Acknowledgement/Funding: This study has been financially supported by The Danish Heart Foundation.
Purpose: The objective of this study was to investigate the association between ALA intake and development of incident PAD.
Methods: This prospective study was based on data from the Danish Diet, Cancer and Health cohort (n=57,053). This cohort of middle-aged men and women was established between 1993 and 1997 and has been followed onwards by record linkage with the Danish National Patient Register. Potential cases of PAD were identified and subsequently validated. Dietary intake of ALA was assessed using a validated food frequency questionnaire. Statistical analyses were performed using Cox proportional hazard regression allowing for separate baseline hazards among genders and adjusted for established risk factors for PAD.
Results: During a median of 13.6 years of follow-up, we identified 950 cases of PAD with complete information on covariates. The median energy-adjusted ALA intake was 1.76 g/d (95% central range: 0.94–3.28 g/d). In multivariable analyses, we observed a weak inverse U-shaped association between quintiles of energy-adjusted ALA intake and the risk of PAD. However, using the first quintile as reference the individual hazard ratios (HRs) for the second (HR: 1.08, 95% CI: 0.85–1.38), third (HR: 1.14, 95% CI: 0.91–1.45), fourth (HR: 1.10, 95% CI: 0.87–1.40) and fifth quintile (HR: 1.05, 95% CI: 0.83–1.34) were not statistically significant. Similar patterns were observed in gender-specific analyses.
Conclusion: This study does not suggest that dietary intake of ALA is appreciably associated with the risk of PAD.
Acknowledgement/Funding: This study has been financially supported by The Danish Heart Foundation.
| Original language | English |
|---|---|
| Journal | European Heart Journal |
| Volume | 39 |
| Issue number | Suppl. 1 |
| Pages (from-to) | 323-323 |
| ISSN | 0195-668X |
| Publication status | Published - 2018 |
| Event | ESC Congress 2018 - Munich, Germany Duration: 25 Aug 2018 → 29 Aug 2018 |
Conference
| Conference | ESC Congress 2018 |
|---|---|
| Country/Territory | Germany |
| City | Munich |
| Period | 25/08/2018 → 29/08/2018 |
