Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Francesca L. Crowe; Timothy J. Key; Paul N. Appleby; Ruth C. Travis; Kim Overvad; Marianne Uhre Jakobsen; Nina F. Johnsen; Anne Tjonneland; Jakob Linseisen; Sabine Rohrmann; Heiner Boeing; Tobias Pischon; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Carlotta Sacerdote; Domenico Palli; Rosario Tumino; Vitorrio Krogh; H. Bas Bueno-de-Mesquita; Lambertus A. Kiemeney; Maria-Dolores Chirlaque; Eva Ardanaz; Maria-Jose Sanchez; Nerea Larranaga; Carlos A. Gonzalez; Jose R. Quiros; Jonas Manjer; Elisabet Wirfalt; Par Stattin; Goran Hallmans; Kay-Tee Khaw; Sheila Bingham; Pietro Ferrari; Nadia Slimani; Mazda Jenab; Elio Riboli

Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Francesca L. Crowe, Timothy J. Key, Paul N. Appleby, Ruth C. Travis, Kim Overvad, Marianne Uhre Jakobsen, Nina F. Johnsen, Anne Tjonneland, Jakob Linseisen, Sabine Rohrmann, Heiner Boeing, Tobias Pischon, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Carlotta Sacerdote, Domenico Palli, Rosario Tumino, Vitorrio Krogh, H. Bas Bueno-de-MesquitaLambertus A. Kiemeney, Maria-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sanchez, Nerea Larranaga, Carlos A. Gonzalez, Jose R. Quiros, Jonas Manjer, Elisabet Wirfalt, Par Stattin, Goran Hallmans, Kay-Tee Khaw, Sheila Bingham, Pietro Ferrari, Nadia Slimani, Mazda Jenab, Elio Riboli

Aarhus University Hospital

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.

Original language	English
Journal	AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume	87
Issue number	5
Pages (from-to)	1405-1413
Number of pages	9
ISSN	0002-9165
Publication status	Published - 2008
Externally published	Yes

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Crowe, F. L., Key, T. J., Appleby, P. N., Travis, R. C., Overvad, K., Jakobsen, M. U., Johnsen, N. F., Tjonneland, A., Linseisen, J., Rohrmann, S., Boeing, H., Pischon, T., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Sacerdote, C., Palli, D., Tumino, R., Krogh, V., ... Riboli, E. (2008). Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. AMERICAN JOURNAL OF CLINICAL NUTRITION, 87(5), 1405-1413.

@article{06d60688ebf04fb1abfb4ceeee3c6839,

title = "Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.",

author = "Crowe, {Francesca L.} and Key, {Timothy J.} and Appleby, {Paul N.} and Travis, {Ruth C.} and Kim Overvad and Jakobsen, {Marianne Uhre} and Johnsen, {Nina F.} and Anne Tjonneland and Jakob Linseisen and Sabine Rohrmann and Heiner Boeing and Tobias Pischon and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Carlotta Sacerdote and Domenico Palli and Rosario Tumino and Vitorrio Krogh and Bueno-de-Mesquita, {H. Bas} and Kiemeney, {Lambertus A.} and Maria-Dolores Chirlaque and Eva Ardanaz and Maria-Jose Sanchez and Nerea Larranaga and Gonzalez, {Carlos A.} and Quiros, {Jose R.} and Jonas Manjer and Elisabet Wirfalt and Par Stattin and Goran Hallmans and Kay-Tee Khaw and Sheila Bingham and Pietro Ferrari and Nadia Slimani and Mazda Jenab and Elio Riboli",

year = "2008",

language = "English",

volume = "87",

pages = "1405--1413",

journal = "AMERICAN JOURNAL OF CLINICAL NUTRITION",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "5",

}

Crowe, FL, Key, TJ, Appleby, PN, Travis, RC, Overvad, K, Jakobsen, MU, Johnsen, NF, Tjonneland, A, Linseisen, J, Rohrmann, S, Boeing, H, Pischon, T, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Krogh, V, Bueno-de-Mesquita, HB, Kiemeney, LA, Chirlaque, M-D, Ardanaz, E, Sanchez, M-J, Larranaga, N, Gonzalez, CA, Quiros, JR, Manjer, J, Wirfalt, E, Stattin, P, Hallmans, G, Khaw, K-T, Bingham, S, Ferrari, P, Slimani, N, Jenab, M & Riboli, E 2008, 'Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition', AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 87, no. 5, pp. 1405-1413.

TY - JOUR

T1 - Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

AU - Crowe, Francesca L.

AU - Key, Timothy J.

AU - Appleby, Paul N.

AU - Travis, Ruth C.

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Johnsen, Nina F.

AU - Tjonneland, Anne

AU - Linseisen, Jakob

AU - Rohrmann, Sabine

AU - Boeing, Heiner

AU - Pischon, Tobias

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Sacerdote, Carlotta

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Krogh, Vitorrio

AU - Bueno-de-Mesquita, H. Bas

AU - Kiemeney, Lambertus A.

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Sanchez, Maria-Jose

AU - Larranaga, Nerea

AU - Gonzalez, Carlos A.

AU - Quiros, Jose R.

AU - Manjer, Jonas

AU - Wirfalt, Elisabet

AU - Stattin, Par

AU - Hallmans, Goran

AU - Khaw, Kay-Tee

AU - Bingham, Sheila

AU - Ferrari, Pietro

AU - Slimani, Nadia

AU - Jenab, Mazda

AU - Riboli, Elio

PY - 2008

Y1 - 2008

N2 - Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.

AB - Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.

M3 - Journal article

SN - 0002-9165

VL - 87

SP - 1405

EP - 1413

JO - AMERICAN JOURNAL OF CLINICAL NUTRITION

JF - AMERICAN JOURNAL OF CLINICAL NUTRITION

IS - 5

ER -

Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Abstract

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