Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs

Per T. Sangild; Richard H. Siggers; Mette Schmidt; Jan Elnif; Charlotte R. Bjornvad; Thomas Thymann; Marie L. Grøndahl; Axel K. Hansen; Søren K. Jensen; Mette Boye; Lars Mølbak; Randal K. Buddington; Bjørn R. Westrom; Jens J. Holst; Douglas G. Burrin

doi:10.1053/j.gastro.2006.02.026

Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs

Per T. Sangild
, Richard H. Siggers
, Mette Schmidt
, Jan Elnif
, Charlotte R. Bjornvad
, Thomas Thymann
, Marie L. Grøndahl
, Axel K. Hansen
, Søren K. Jensen
, Mette Boye
, Lars Mølbak
, Randal K. Buddington
, Bjørn R. Westrom
, Jens J. Holst
, Douglas G. Burrin

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P

Original language	English
Journal	Gastroenterology
Volume	130
Issue number	6
Pages (from-to)	1776-1792
ISSN	0016-5085
DOIs	https://doi.org/10.1053/j.gastro.2006.02.026
Publication status	Published - 2006

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Sangild, P. T., Siggers, R. H., Schmidt, M., Elnif, J., Bjornvad, C. R., Thymann, T., Grøndahl, M. L., Hansen, A. K., Jensen, S. K., Boye, M., Mølbak, L., Buddington, R. K., Westrom, B. R., Holst, J. J., & Burrin, D. G. (2006). Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Gastroenterology, 130(6), 1776-1792. https://doi.org/10.1053/j.gastro.2006.02.026

@article{6f5608f6d16c4dbd9b5b7cd6c8e62fe4,

title = "Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs",

abstract = "Background \& Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92\% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57\% of pigs fed FORMULA (26/46) and in 5\% of pigs fed COLOSTRUM (2/38) (P ",

author = "Sangild, \{Per T.\} and Siggers, \{Richard H.\} and Mette Schmidt and Jan Elnif and Bjornvad, \{Charlotte R.\} and Thomas Thymann and Gr{\o}ndahl, \{Marie L.\} and Hansen, \{Axel K.\} and Jensen, \{S{\o}ren K.\} and Mette Boye and Lars M{\o}lbak and Buddington, \{Randal K.\} and Westrom, \{Bj{\o}rn R.\} and Holst, \{Jens J.\} and Burrin, \{Douglas G.\}",

year = "2006",

doi = "10.1053/j.gastro.2006.02.026",

language = "English",

volume = "130",

pages = "1776--1792",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "6",

}

Sangild, PT, Siggers, RH, Schmidt, M, Elnif, J, Bjornvad, CR, Thymann, T, Grøndahl, ML, Hansen, AK, Jensen, SK, Boye, M, Mølbak, L, Buddington, RK, Westrom, BR, Holst, JJ & Burrin, DG 2006, 'Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs', Gastroenterology, vol. 130, no. 6, pp. 1776-1792. https://doi.org/10.1053/j.gastro.2006.02.026

TY - JOUR

T1 - Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs

AU - Sangild, Per T.

AU - Siggers, Richard H.

AU - Schmidt, Mette

AU - Elnif, Jan

AU - Bjornvad, Charlotte R.

AU - Thymann, Thomas

AU - Grøndahl, Marie L.

AU - Hansen, Axel K.

AU - Jensen, Søren K.

AU - Boye, Mette

AU - Mølbak, Lars

AU - Buddington, Randal K.

AU - Westrom, Bjørn R.

AU - Holst, Jens J.

AU - Burrin, Douglas G.

PY - 2006

Y1 - 2006

N2 - Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P

AB - Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P

U2 - 10.1053/j.gastro.2006.02.026

DO - 10.1053/j.gastro.2006.02.026

M3 - Journal article

SN - 0016-5085

VL - 130

SP - 1776

EP - 1792

JO - Gastroenterology

JF - Gastroenterology

IS - 6

ER -

Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs

Abstract

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