Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs

Per T. Sangild, Richard H. Siggers, Mette Schmidt, Jan Elnif, Charlotte R. Bjornvad, Thomas Thymann, Marie L. Grøndahl, Axel K. Hansen, Søren K. Jensen, Mette Boye, Lars Mølbak, Randal K. Buddington, Bjørn R. Westrom, Jens J. Holst, Douglas G. Burrin

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P
    Original languageEnglish
    JournalGastroenterology
    Volume130
    Issue number6
    Pages (from-to)1776-1792
    ISSN0016-5085
    DOIs
    Publication statusPublished - 2006

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