A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.
Ishøy, M., Petersen, R., Petersen, M. Å., Wu, P., Clausen, M. H., & Nielsen, T. E. (2017). Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions. Chemical Communications, 53(68), 9410-9413. https://doi.org/10.1039/C7CC02948A