Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

Mette Ishøy; Rico Petersen; Michael Åxman Petersen; Peng Wu; Mads Hartvig Clausen; Thomas Eiland Nielsen

doi:10.1039/C7CC02948A

Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

Mette Ishøy, Rico Petersen, Michael Åxman Petersen, Peng Wu, Mads Hartvig Clausen, Thomas Eiland Nielsen

Department of Chemistry

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Abstract

A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp³-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.

Original language	English
Journal	Chemical Communications
Volume	53
Issue number	68
Pages (from-to)	9410-9413
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/C7CC02948A
Publication status	Published - 2017

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title = "Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions",

abstract = "A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.",

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year = "2017",

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language = "English",

volume = "53",

pages = "9410--9413",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

AU - Ishøy, Mette

AU - Petersen, Rico

AU - Petersen, Michael Åxman

AU - Wu, Peng

AU - Clausen, Mads Hartvig

AU - Nielsen, Thomas Eiland

PY - 2017

Y1 - 2017

N2 - A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.

AB - A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.

U2 - 10.1039/C7CC02948A

DO - 10.1039/C7CC02948A

M3 - Journal article

SN - 1359-7345

VL - 53

SP - 9410

EP - 9413

JO - Chemical Communications

JF - Chemical Communications

IS - 68

ER -

Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

Abstract

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