Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

Mette Ishøy, Rico Petersen, Michael Åxman Petersen, Peng Wu, Mads Hartvig Clausen, Thomas Eiland Nielsen

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Abstract

A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis is provided.
Original languageEnglish
JournalChemical Communications
Volume53
Issue number68
Pages (from-to)9410-9413
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 2017

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