Device, method and system for preparing microcapsules

Helena Paula de Sousa Sepúlveda Azevedo (Inventor), Erkan Türker Baran (Inventor), Ana Carina Loureiro Mendes (Inventor), Rui Luis Gonçalves dos Reis (Inventor)

Research output: Patent

53 Downloads (Pure)

Abstract

The invention discloses a novel device for the formation of microcapsules based on micro-droplet generation inside silicone tubing, which is punctured with a blunt-ended syringe needle vertically (1). The device uses droplet generation by vertical injection of hydrophilic polymer/cell mixture into hydrophobic oil flow, which is horizontally maintained in the silicone tubing. The injection of polymer/cell mixture into a stream of mineral oil results in the generation of spherical droplet and in the formation of a water- in-oil emulsion due to the immiscibility of the two phases. Subsequently, the micro-droplets in oil phase are converted into stable microcapsules by gelation in a separate chamber which is loaded with ionic cross- linking solution at physiological ionic strength and pH. The utility of the microcapsules generated by the device of present invention is virtually unlimited in the fields of regenerative medicine, controlled delivery of growth factor or drug
Original languageEnglish
IPCB01J13/00
Patent numberWO 2012099482 A8
Filing date13/09/2012
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Publication statusPublished - 2014

Cite this

Azevedo, H. P. D. S. S., Baran, E. T., Mendes, A. C. L., & Reis, R. L. G. D. (2014). IPC No. B01J13/00. Device, method and system for preparing microcapsules. (Patent No. WO 2012099482 A8).
Azevedo, Helena Paula de Sousa Sepúlveda (Inventor) ; Baran, Erkan Türker (Inventor) ; Mendes, Ana Carina Loureiro (Inventor) ; Reis, Rui Luis Gonçalves dos (Inventor). / Device, method and system for preparing microcapsules. IPC No.: B01J13/00. Patent No.: WO 2012099482 A8. Sep 13, 2012.
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abstract = "The invention discloses a novel device for the formation of microcapsules based on micro-droplet generation inside silicone tubing, which is punctured with a blunt-ended syringe needle vertically (1). The device uses droplet generation by vertical injection of hydrophilic polymer/cell mixture into hydrophobic oil flow, which is horizontally maintained in the silicone tubing. The injection of polymer/cell mixture into a stream of mineral oil results in the generation of spherical droplet and in the formation of a water- in-oil emulsion due to the immiscibility of the two phases. Subsequently, the micro-droplets in oil phase are converted into stable microcapsules by gelation in a separate chamber which is loaded with ionic cross- linking solution at physiological ionic strength and pH. The utility of the microcapsules generated by the device of present invention is virtually unlimited in the fields of regenerative medicine, controlled delivery of growth factor or drug",
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Azevedo, HPDSS, Baran, ET, Mendes, ACL & Reis, RLGD Sep. 13 2012, Device, method and system for preparing microcapsules, Patent No. WO 2012099482 A8, IPC No. B01J13/00.

Device, method and system for preparing microcapsules. / Azevedo, Helena Paula de Sousa Sepúlveda (Inventor); Baran, Erkan Türker (Inventor); Mendes, Ana Carina Loureiro (Inventor); Reis, Rui Luis Gonçalves dos (Inventor).

IPC No.: B01J13/00. Patent No.: WO 2012099482 A8. Sep 13, 2012.

Research output: Patent

TY - PAT

T1 - Device, method and system for preparing microcapsules

AU - Azevedo, Helena Paula de Sousa Sepúlveda

AU - Baran, Erkan Türker

AU - Mendes, Ana Carina Loureiro

AU - Reis, Rui Luis Gonçalves dos

PY - 2014

Y1 - 2014

N2 - The invention discloses a novel device for the formation of microcapsules based on micro-droplet generation inside silicone tubing, which is punctured with a blunt-ended syringe needle vertically (1). The device uses droplet generation by vertical injection of hydrophilic polymer/cell mixture into hydrophobic oil flow, which is horizontally maintained in the silicone tubing. The injection of polymer/cell mixture into a stream of mineral oil results in the generation of spherical droplet and in the formation of a water- in-oil emulsion due to the immiscibility of the two phases. Subsequently, the micro-droplets in oil phase are converted into stable microcapsules by gelation in a separate chamber which is loaded with ionic cross- linking solution at physiological ionic strength and pH. The utility of the microcapsules generated by the device of present invention is virtually unlimited in the fields of regenerative medicine, controlled delivery of growth factor or drug

AB - The invention discloses a novel device for the formation of microcapsules based on micro-droplet generation inside silicone tubing, which is punctured with a blunt-ended syringe needle vertically (1). The device uses droplet generation by vertical injection of hydrophilic polymer/cell mixture into hydrophobic oil flow, which is horizontally maintained in the silicone tubing. The injection of polymer/cell mixture into a stream of mineral oil results in the generation of spherical droplet and in the formation of a water- in-oil emulsion due to the immiscibility of the two phases. Subsequently, the micro-droplets in oil phase are converted into stable microcapsules by gelation in a separate chamber which is loaded with ionic cross- linking solution at physiological ionic strength and pH. The utility of the microcapsules generated by the device of present invention is virtually unlimited in the fields of regenerative medicine, controlled delivery of growth factor or drug

M3 - Patent

M1 - WO 2012099482 A8

Y2 - 2012/09/13

ER -

Azevedo HPDSS, Baran ET, Mendes ACL, Reis RLGD, inventors. Device, method and system for preparing microcapsules. B01J13/00. 2014.