Development, optimisation, and application of ICP-SFMS methods for the measurement of isotope ratios

Stefan Sturup

    Research output: Book/ReportPh.D. thesisResearch

    64 Downloads (Pure)

    Abstract

    The measurement of isotopic composition and isotope ratios in biological and
    environmental samples requires sensitive, precise, and accurate analytical techniques. The analytical techniques used are traditionally based on mass spectrometry, among these techniques is the ICP-SFMS technique, which became commercially available in the mid 1990s. This technique is characterised by high sensitivity, low background, and the ability to separate analyte signals from spectral interferences. These features are beneficial for the measurement of isotope ratios and enable the measurement of isotope ratios of elements, which it has not previously been possible to measure due to either spectral interferences or poor sensitivity.

    The overall purpose of the project was to investigate the potential of the single detector ICPSFMS technique for the measurement of isotope ratios in biological and environmental samples. One part of the work has focused on the fundamental aspects of the ICP-SFMS technique with special emphasize on the features important to the measurement of isotope ratios, while another part has focused on the development, optimisation and application of specific methods for the measurement of isotope ratios of elements of nutritional interest and radionuclides.

    The fundamental aspects of the ICP-SFMS technique were investigated theoretically and experimentally by the measurement of isotope ratios applying different experimental conditions. It was demonstrated that isotope ratios could be measured reliably using ICPSFMS by educated choice of acquisition parameters, scanning mode, mass discrimination correction, and by eliminating the influence of detector dead time.

    Applying the knowledge gained through the fundamental study, ICP-SFMS methods for the measurement of isotope ratios of calcium, zinc, molybdenum and iron in human samples and a method for the measurement of plutonium isotope ratios and ultratrace levels of plutonium and neptunium in environmental samples were developed. The figures of merit of these methods demonstrated that isotope ratios could be measured with good precision and accuracy by ICP-SFMS.
    Original languageEnglish
    Place of PublicationRoskilde
    PublisherRisø National Laboratory
    Number of pages127
    ISBN (Print)87-550-2715-6
    ISBN (Electronic)87-550-2738-5
    Publication statusPublished - 2000
    SeriesDenmark. Forskningscenter Risoe. Risoe-R
    Number1192(EN)
    ISSN0106-2840

    Keywords

    • Risø-R-1192(EN)
    • Risø-R-1192

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