Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

Oscar Nieves; David Ortiz de Zárate; Elena Aznar; Isabel Caballos; Eva Garrido; Ramón Martínez-Máñez; Fabian Dortu; Damien Bernier; Beatriz Mengual-Chuliá; F. Xavier López-Labrador; Jens J. Sloth; Katrin Loeschner; Lene Duedahl-Olesen; Natalia Prado; Martín Hervello; Armando Menéndez; Rainer Gransee; Thomas Klotzbuecher; M. Clara Gonçalves; Fahimeh Zare; Ana Fuentes López; Isabel Fernández Segovia; Jose M. Barat Baviera; Jaime Salcedo; Sara Recuero; Santiago Simón; Ana Fernández Blanco; Sergio Peransi; Maribel Gómez-Gómez; Amadeu Griol

doi:10.3390/s23208548

Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

Oscar Nieves, David Ortiz de Zárate, Elena Aznar, Isabel Caballos, Eva Garrido, Ramón Martínez-Máñez, Fabian Dortu, Damien Bernier, Beatriz Mengual-Chuliá, F. Xavier López-Labrador, Jens J. Sloth, Katrin Loeschner, Lene Duedahl-Olesen, Natalia Prado, Martín Hervello, Armando Menéndez, Rainer Gransee, Thomas Klotzbuecher, M. Clara Gonçalves, Fahimeh ZareAna Fuentes López, Isabel Fernández Segovia, Jose M. Barat Baviera, Jaime Salcedo, Sara Recuero, Santiago Simón, Ana Fernández Blanco, Sergio Peransi, Maribel Gómez-Gómez^*, Amadeu Griol^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission-founded PHOTONGATE project. This concept will allow for the quantification of multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions. PHOTONGATE relies on two core technologies: a biochemical technology (molecular gates), which will confer the specificity and, therefore, the capability to be adaptable to the analyte of interest, and which, combined with porous substrates, will increase the sensitivity, and a photonic technology based on localized surface plasmonic resonance (LSPR) structures that serve as transducers for light interaction. Both technologies are in the micron range, facilitating the integration of multiple sensors within a small area (mm²). The concept will be developed for its application in health diagnosis and food safety sectors. It is thought of as an easy-to-use modular concept, which will consist of the sensing module, mainly of a microfluidics cartridge that will house the photonic sensor, and a platform for fluidic handling, optical interrogation, and signal processing. The platform will include a new optical concept, which is fully European Union Made, avoiding optical fibers and expensive optical components.

Original language	English
Article number	8548
Journal	Sensors
Volume	23
Issue number	20
Number of pages	13
ISSN	1424-3210
DOIs	https://doi.org/10.3390/s23208548
Publication status	Published - 2023

Bibliographical note

This research project has received funding from the European Union’s HORIZON-CL4-2022 research and innovation programme under grant agreement ID 101093042, PHOTONGATE project.

Keywords

Photonics
Molecular gates
Localized surface plasmonic resonance (LSPR)
Porous silica
Biosensing
Microfluidics
Respiratory viruses
Chemical contaminants

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Nieves, O., de Zárate, D. O., Aznar, E., Caballos, I., Garrido, E., Martínez-Máñez, R., Dortu, F., Bernier, D., Mengual-Chuliá, B., López-Labrador, F. X., Sloth, J. J., Loeschner, K., Duedahl-Olesen, L., Prado, N., Hervello, M., Menéndez, A., Gransee, R., Klotzbuecher, T., Gonçalves, M. C., ... Griol, A. (2023). Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project. Sensors, 23(20), Article 8548. https://doi.org/10.3390/s23208548

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abstract = "This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission-founded PHOTONGATE project. This concept will allow for the quantification of multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions. PHOTONGATE relies on two core technologies: a biochemical technology (molecular gates), which will confer the specificity and, therefore, the capability to be adaptable to the analyte of interest, and which, combined with porous substrates, will increase the sensitivity, and a photonic technology based on localized surface plasmonic resonance (LSPR) structures that serve as transducers for light interaction. Both technologies are in the micron range, facilitating the integration of multiple sensors within a small area (mm2). The concept will be developed for its application in health diagnosis and food safety sectors. It is thought of as an easy-to-use modular concept, which will consist of the sensing module, mainly of a microfluidics cartridge that will house the photonic sensor, and a platform for fluidic handling, optical interrogation, and signal processing. The platform will include a new optical concept, which is fully European Union Made, avoiding optical fibers and expensive optical components.",

keywords = "Photonics, Molecular gates, Localized surface plasmonic resonance (LSPR), Porous silica, Biosensing, Microfluidics, Respiratory viruses, Chemical contaminants",

author = "Oscar Nieves and {de Z{\'a}rate}, {David Ortiz} and Elena Aznar and Isabel Caballos and Eva Garrido and Ram{\'o}n Mart{\'i}nez-M{\'a}{\~n}ez and Fabian Dortu and Damien Bernier and Beatriz Mengual-Chuli{\'a} and L{\'o}pez-Labrador, {F. Xavier} and Sloth, {Jens J.} and Katrin Loeschner and Lene Duedahl-Olesen and Natalia Prado and Mart{\'i}n Hervello and Armando Men{\'e}ndez and Rainer Gransee and Thomas Klotzbuecher and Gon{\c c}alves, {M. Clara} and Fahimeh Zare and L{\'o}pez, {Ana Fuentes} and {Fern{\'a}ndez Segovia}, Isabel and Baviera, {Jose M. Barat} and Jaime Salcedo and Sara Recuero and Santiago Sim{\'o}n and {Fern{\'a}ndez Blanco}, Ana and Sergio Peransi and Maribel G{\'o}mez-G{\'o}mez and Amadeu Griol",

note = "This research project has received funding from the European Union{\textquoteright}s HORIZON-CL4-2022 research and innovation programme under grant agreement ID 101093042, PHOTONGATE project.",

year = "2023",

doi = "10.3390/s23208548",

language = "English",

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Nieves, O, de Zárate, DO, Aznar, E, Caballos, I, Garrido, E, Martínez-Máñez, R, Dortu, F, Bernier, D, Mengual-Chuliá, B, López-Labrador, FX, Sloth, JJ , Loeschner, K , Duedahl-Olesen, L, Prado, N, Hervello, M, Menéndez, A, Gransee, R, Klotzbuecher, T, Gonçalves, MC, Zare, F, López, AF, Fernández Segovia, I, Baviera, JMB, Salcedo, J, Recuero, S, Simón, S, Fernández Blanco, A, Peransi, S, Gómez-Gómez, M & Griol, A 2023, 'Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project', Sensors, vol. 23, no. 20, 8548. https://doi.org/10.3390/s23208548

TY - JOUR

T1 - Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

AU - Nieves, Oscar

AU - de Zárate, David Ortiz

AU - Aznar, Elena

AU - Caballos, Isabel

AU - Garrido, Eva

AU - Martínez-Máñez, Ramón

AU - Dortu, Fabian

AU - Bernier, Damien

AU - Mengual-Chuliá, Beatriz

AU - López-Labrador, F. Xavier

AU - Sloth, Jens J.

AU - Loeschner, Katrin

AU - Duedahl-Olesen, Lene

AU - Prado, Natalia

AU - Hervello, Martín

AU - Menéndez, Armando

AU - Gransee, Rainer

AU - Klotzbuecher, Thomas

AU - Gonçalves, M. Clara

AU - Zare, Fahimeh

AU - López, Ana Fuentes

AU - Fernández Segovia, Isabel

AU - Baviera, Jose M. Barat

AU - Salcedo, Jaime

AU - Recuero, Sara

AU - Simón, Santiago

AU - Fernández Blanco, Ana

AU - Peransi, Sergio

AU - Gómez-Gómez, Maribel

AU - Griol, Amadeu

N1 - This research project has received funding from the European Union’s HORIZON-CL4-2022 research and innovation programme under grant agreement ID 101093042, PHOTONGATE project.

PY - 2023

Y1 - 2023

N2 - This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission-founded PHOTONGATE project. This concept will allow for the quantification of multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions. PHOTONGATE relies on two core technologies: a biochemical technology (molecular gates), which will confer the specificity and, therefore, the capability to be adaptable to the analyte of interest, and which, combined with porous substrates, will increase the sensitivity, and a photonic technology based on localized surface plasmonic resonance (LSPR) structures that serve as transducers for light interaction. Both technologies are in the micron range, facilitating the integration of multiple sensors within a small area (mm2). The concept will be developed for its application in health diagnosis and food safety sectors. It is thought of as an easy-to-use modular concept, which will consist of the sensing module, mainly of a microfluidics cartridge that will house the photonic sensor, and a platform for fluidic handling, optical interrogation, and signal processing. The platform will include a new optical concept, which is fully European Union Made, avoiding optical fibers and expensive optical components.

AB - This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission-founded PHOTONGATE project. This concept will allow for the quantification of multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions. PHOTONGATE relies on two core technologies: a biochemical technology (molecular gates), which will confer the specificity and, therefore, the capability to be adaptable to the analyte of interest, and which, combined with porous substrates, will increase the sensitivity, and a photonic technology based on localized surface plasmonic resonance (LSPR) structures that serve as transducers for light interaction. Both technologies are in the micron range, facilitating the integration of multiple sensors within a small area (mm2). The concept will be developed for its application in health diagnosis and food safety sectors. It is thought of as an easy-to-use modular concept, which will consist of the sensing module, mainly of a microfluidics cartridge that will house the photonic sensor, and a platform for fluidic handling, optical interrogation, and signal processing. The platform will include a new optical concept, which is fully European Union Made, avoiding optical fibers and expensive optical components.

KW - Photonics

KW - Molecular gates

KW - Localized surface plasmonic resonance (LSPR)

KW - Porous silica

KW - Biosensing

KW - Microfluidics

KW - Respiratory viruses

KW - Chemical contaminants

U2 - 10.3390/s23208548

DO - 10.3390/s23208548

M3 - Journal article

C2 - 37896641

SN - 1424-3210

VL - 23

JO - Sensors

JF - Sensors

IS - 20

M1 - 8548

ER -

Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

Abstract

Bibliographical note

Keywords

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