Development of peptidic anti-­dendrotoxins

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Abstract

The black mamba (Dendroaspis polylepis) is one of the most feared and dangerous snakes in the world, and its bite has a very high mortality and morbidity rate. Dendrotoxins, the most abundant and some of the most toxic components present in black mamba venom, target potassium channels in neuronal tissue, leading to hyper-excitability in victims and prey. Blockage of the potassium channels can lead to respiratory paralysis and eventually death. Early administration of appropriate antivenom is the only effective snakebite therapy to date. However, current antivenoms are still being produced by the very laborious and expensive traditional animal immunization techniques, leading to severe side effects in human recipients due to their heterologous nature. In contrast, novel approaches based on synthetic or recombinant antivenoms may offer an alternative solution, saving cost, limiting side effects, and providing more effective neutralization of snake venom.
Original languageEnglish
Publication date2016
Number of pages1
Publication statusPublished - 2016
Event14th Protein.DTU Workshop: Applied Protein Science - Technical University of denmark, Kgs. Lyngby, Denmark
Duration: 9 May 20169 May 2016
Conference number: 14

Workshop

Workshop14th Protein.DTU Workshop
Number14
LocationTechnical University of denmark
CountryDenmark
CityKgs. Lyngby
Period09/05/201609/05/2016

Bibliographical note

For poster presentation.

Cite this

Oscoz, S., Laustsen, A. H., Clausen, M. H., & Lohse, B. (2016). Development of peptidic anti-­dendrotoxins. Abstract from 14th Protein.DTU Workshop, Kgs. Lyngby, Denmark.