Development of electrosprayed mucoadhesive chitosan microparticles

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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Development of electrosprayed mucoadhesive chitosan microparticles. / Moreno, Jorge Alberto S.; Mendes, Ana C.; Stephansen, Karen; Engwer, Christoph; Goycoolea, Francisco M.; Boisen, Anja; Nielsen, Line Hagner; Chronakis, Ioannis S.

In: Carbohydrate Polymers, Vol. 190, 2018, p. 240-247.

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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@article{ae075e7499d54d729aafa731e899ea50,
title = "Development of electrosprayed mucoadhesive chitosan microparticles",
abstract = "The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3{\%} w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50{\%} v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.",
keywords = "Electrospray, Microparticles, Chitosan, Mucoadhesion, Electrohydrodynamics, Polysaccharide",
author = "Moreno, {Jorge Alberto S.} and Mendes, {Ana C.} and Karen Stephansen and Christoph Engwer and Goycoolea, {Francisco M.} and Anja Boisen and Nielsen, {Line Hagner} and Chronakis, {Ioannis S.}",
year = "2018",
doi = "10.1016/j.carbpol.2018.02.062",
language = "English",
volume = "190",
pages = "240--247",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Development of electrosprayed mucoadhesive chitosan microparticles

AU - Moreno, Jorge Alberto S.

AU - Mendes, Ana C.

AU - Stephansen, Karen

AU - Engwer, Christoph

AU - Goycoolea, Francisco M.

AU - Boisen, Anja

AU - Nielsen, Line Hagner

AU - Chronakis, Ioannis S.

PY - 2018

Y1 - 2018

N2 - The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.

AB - The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.

KW - Electrospray

KW - Microparticles

KW - Chitosan

KW - Mucoadhesion

KW - Electrohydrodynamics

KW - Polysaccharide

U2 - 10.1016/j.carbpol.2018.02.062

DO - 10.1016/j.carbpol.2018.02.062

M3 - Journal article

VL - 190

SP - 240

EP - 247

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -