Development of electrosprayed mucoadhesive chitosan microparticles

Jorge Alberto S. Moreno, Ana C. Mendes*, Karen Stephansen, Christoph Engwer, Francisco M. Goycoolea, Anja Boisen, Line Hagner Nielsen, Ioannis S. Chronakis

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.
Original languageEnglish
JournalCarbohydrate Polymers
Volume190
Pages (from-to)240-247
ISSN0144-8617
DOIs
Publication statusPublished - 2018

Keywords

  • Electrospray
  • Microparticles
  • Chitosan
  • Mucoadhesion
  • Electrohydrodynamics
  • Polysaccharide

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