Projects per year
Photo-cleavable protecting groups are highly applicable for the synthesis of structural complex and sensitive compounds, including biological important molecules. Herein, we present the development of a novel O-hydroxylamine photo-cleavable protecting group, based on the methyl-6-nitroveratryl moiety. We demonstrate the application of the protected hydroxylamine derivative for the synthesis of N-alkylated hydroxamic acids. We have shown that the construct is stable toward a diverse set of reaction conditions, as well as orthogonal with conventional protection groups. The O-protected hydroxylamine derivative was applied to synthesize a small collection of N-alkylated hydroxamic acids as inhibitors of the histone deacetylase enzymes, an important class of enzymes for the treatment of a range of diseases, most importantly cancer. During my external stay at Nanyang Technological University, Singapore, I worked on a project with the aim of synthesizing compounds that target the quorum sensing network in Pseudomonas aeruginosa, important for the treatment of bacterial infections. The structure was based on a recent found hit compound, by our collaborators in Singapore, showing high activity.
|Number of pages||271|
|Publication status||Published - 2017|
01/09/2013 → 21/06/2017