Development of a study protocol for thyroid disruptor testing in the mammalian system: Deliverable 16: final feasibility study report

The present project aims to fill a significant gap in test guidelines for endocrine disruptors: The lack of a test method that can capture the detrimental effects on brain development due to thyroid hormone insufficiency during foetal and neonatal life. This document describes the outcome of a study that explored the feasibility of identifying periventricular heterotopia – clusters of misplaced cells in the corpus callosum – after exposure to test chemicals that produce suppressions of circulating thyroid hormone levels in foetal and neonatal life. In line with the technical specifications for this service request, the development of this Deliverable 16 is based on: The preparation of a scoping document of possible test methods or endpoints, the development of a draft study protocol and a roadmap for the feasibility study, and the conduct of the feasibility study itself.