Development of a Sono-Assembled, Bifunctional Soy Peptide Nanoparticle for Cellular Delivery of Hydrophobic Active Cargoes

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

DOI

  • Author: Zhang, Yuanhong

    South China University of Technology, China

  • Author: Zhao, Mouming

    South China University of Technology, China

  • Author: Ning, Zhengxiang

    South China University of Technology, China

  • Author: Yu, Shujuan

    South China University of Technology, China

  • Author: Tang, Ning

    Department of Chemistry, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Zhou, Feibai

    South China University of Technology, China

View graph of relations

Soy proteins are prone to aggregate upon proteolysis, hindering their sustainable development in food processing. Here, a continuous work on the large insoluble peptide aggregates was carried out, aiming to develop a new type of soy peptide-based nanoparticle (SPN) for active cargo delivery. Sono-assembled SPN in spherical appearance and core-shell structure maintained by noncovalent interactions was successfully fabricated, exhibiting small particle size (103.95 nm) in a homogeneous distribution state (PDI = 0.18). Curcumin as a model cargo was efficiently encapsulated into SPN upon sonication, showing high water dispersity (129.6 mg/L, 104 higher than its water solubility) and storage stability. Additionally, the pepsin-resistant SPN contributed to the controlled release of curcumin at the intestinal phase and thus significantly improved the bioaccessibility. Encapsulated curcumin was effective in protecting glutamate-induced toxicity in PC12 cells, where the matrix SPN can simultaneously reduce lipid peroxidation and elevate antioxidant enzymes levels, innovatively demonstrating its bifunctionality during cellular delivery.
Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
Volume66
Issue number16
Pages (from-to)4208-4218
ISSN0021-8561
DOIs
Publication statusPublished - 2018
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Bifunctionality, Cellular delivery, Curcumin, Gastric-intestinal release, Soy peptide nanoparticles

ID: 146792733