Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

Vida Krikstolaityte; Tautgirdas Ruzgas; Arto Heiskanen; Chiara Canali; Thomas Arnebrant; Jenny Emnéus

doi:10.1016/j.protcy.2017.04.108

Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

Vida Krikstolaityte^*, Tautgirdas Ruzgas, Arto Heiskanen, Chiara Canali, Thomas Arnebrant, Jenny Emnéus

^*Corresponding author for this work

Malmö University

Research output: Contribution to journal › Conference article › Research › peer-review

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Abstract

In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.

Original language	English
Journal	Procedia Technology
Volume	27
Pages (from-to)	252-253
ISSN	2212-0173
DOIs	https://doi.org/10.1016/j.protcy.2017.04.108
Publication status	Published - 2017
Event	Biosensors 2016: 26th Anniversary World Congress on Biosensors - Swedish Exhibition and Congress Centre, Gothenburg, Sweden Duration: 25 May 2016 → 27 May 2016 Conference number: 26 http://www.biosensors-congress.elsevier.com/

Conference

Conference	Biosensors 2016
Number	26
Location	Swedish Exhibition and Congress Centre
Country/Territory	Sweden
City	Gothenburg
Period	25/05/2016 → 27/05/2016
Internet address	http://www.biosensors-congress.elsevier.com/

Keywords

Poly(methylmethacrylate)
Lab-on-a-chip
Electrochemical impedance spectroscopy
Finite element model simulations

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title = "Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application",

abstract = "In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.",

keywords = "Poly(methylmethacrylate), Lab-on-a-chip, Electrochemical impedance spectroscopy, Finite element model simulations",

author = "Vida Krikstolaityte and Tautgirdas Ruzgas and Arto Heiskanen and Chiara Canali and Thomas Arnebrant and Jenny Emn{\'e}us",

year = "2017",

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T1 - Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

AU - Krikstolaityte, Vida

AU - Ruzgas, Tautgirdas

AU - Heiskanen, Arto

AU - Canali, Chiara

AU - Arnebrant, Thomas

AU - Emnéus, Jenny

N1 - Conference code: 26

PY - 2017

Y1 - 2017

N2 - In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.

AB - In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.

KW - Poly(methylmethacrylate)

KW - Lab-on-a-chip

KW - Electrochemical impedance spectroscopy

KW - Finite element model simulations

U2 - 10.1016/j.protcy.2017.04.108

DO - 10.1016/j.protcy.2017.04.108

M3 - Conference article

SN - 2212-0173

VL - 27

SP - 252

EP - 253

JO - Procedia Technology

JF - Procedia Technology

T2 - Biosensors 2016

Y2 - 25 May 2016 through 27 May 2016

ER -

Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

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Keywords

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