Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

Vida Krikstolaityte*, Tautgirdas Ruzgas, Arto Heiskanen, Chiara Canali, Thomas Arnebrant, Jenny Emnéus

*Corresponding author for this work

    Research output: Contribution to journalConference articleResearchpeer-review

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    In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.
    Original languageEnglish
    JournalProcedia Technology
    Pages (from-to)252-253
    Publication statusPublished - 2017
    EventBiosensors 2016: 26th Anniversary World Congress on Biosensors - Swedish Exhibition and Congress Centre, Gothenburg, Sweden
    Duration: 25 May 201627 May 2016
    Conference number: 26


    ConferenceBiosensors 2016
    LocationSwedish Exhibition and Congress Centre
    Internet address


    • Poly(methylmethacrylate)
    • Lab-on-a-chip
    • Electrochemical impedance spectroscopy
    • Finite element model simulations


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