The hydrogenation of aromatic nitro substrates is a frequently used reaction in the multi-step fabrication of active pharmaceutical ingredients (APIs). Today most pharmaceutical production processes are performed in batch mode. In the frame of the C2-campaign speed is an important factor during the production of a multitude of possible API’s. A generic reactor set-up able to be adapted for the transformation of a specific substrate would reduce the development time and thereby the campaign time significantly. In the frame of the EU-project F3-Factory such a flexible and continuous reaction system for this important reaction class able to produce 1-5 kg API is being developed. To allow for an easy and fast adaptation of this process for a range of nitro substrates a substrates adoption methodology (SAM) is also being developed. A literature study of the nature of different reduction methods (H2 gas, H-Donor, CO gas, etc.) led to the conclusion that the liquid phase reduction of aromatic nitro substrates by either hydrogen gas or an H-donor is the most selective method. Following the requirements of that reaction type a flexible and modular reactor for the liquid phase reduction with a heterogeneous slurry catalyst was designed that can be adapted for reduction of a range of nitro compounds. The generic process provides the possibilities of swapping out a reactor or work up technology as required. The equipments of the generic process should be also able to operate at wider range of operational variables making it suitable for a range of substrates. The SAM identifies the necessary changes to a generic process and plant in order to adapt it for a given substrate. The objectives of this presentation is to highlight the design of a generic nitro reduction process and to demonstrate the application of this generic process on a pharmaceutical manufacturing case study involving the nitro reduction of 6-Nitroquinoline.
|Publication status||Published - 2011|
|Event||8th European Congress of Chemical Engineering - Berlin, Germany|
Duration: 25 Sep 2011 → 29 Sep 2011
Conference number: 8
|Conference||8th European Congress of Chemical Engineering|
|Period||25/09/2011 → 29/09/2011|
Haas-Santo, K., Vankayala, B., Dittmeyer, R., Singh, R., Gernaey, K., Gani, R., Rozada-Sanchez, R., & Muller, F. (2011). Development of a fast and flexible generic process for the reduction of nitro compounds. Abstract from 8th European Congress of Chemical Engineering, Berlin, Germany.