Abstract
The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.
| Original language | English |
|---|---|
| IPC | G01N 33/ 569 A I |
| Patent number | WO2015185067 |
| Filing date | 06/06/2014 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 06/06/2014 |
| Priority number | DK2014PA70340 |
| Publication status | Published - 10 Dec 2015 |
Bibliographical note
Also published as: WO2015185067 (A9) AU2015271324 (A1) CA2951325 (A1) EP3152232 (A1) JP2017518375 (A) SG11201610177U (A) US2017343545 (A1)UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'Determining antigen recognition through barcoding of mhc multimers'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver