Determining antigen recognition through barcoding of mhc multimers

Sine Reker Hadrup; Henrik Pedersen; Søren Jakobsen; Amalie Kai Bentzen

Determining antigen recognition through barcoding of mhc multimers

Sine Reker Hadrup (Inventor), Henrik Pedersen (Inventor), Søren Jakobsen (Inventor), Amalie Kai Bentzen (Inventor)

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Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

Original language	English
IPC	G01N 33/ 569 A I
Patent number	WO2015185067
Filing date	06/06/2014
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	06/06/2014
Priority number	DK2014PA70340
Publication status	Published - 10 Dec 2015

Bibliographical note

Also published as: WO2015185067 (A9) AU2015271324 (A1) CA2951325 (A1) EP3152232 (A1) JP2017518375 (A) SG11201610177U (A) US2017343545 (A1)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.",

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AU - Bentzen, Amalie Kai

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N2 - The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

AB - The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

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Determining antigen recognition through barcoding of mhc multimers

Abstract

Bibliographical note

UN SDGs

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