Determining antigen recognition through barcoding of mhc multimers

Sine Reker Hadrup (Inventor), Henrik Pedersen (Inventor), Søren Jakobsen (Inventor), Amalie Kai Bentzen (Inventor)

Research output: Patent

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Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

Original languageEnglish
IPCG01N 33/ 569 A I
Patent numberWO2015185067
Filing date06/06/2014
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date06/06/2014
Priority numberDK2014PA70340
Publication statusPublished - 10 Dec 2015

Bibliographical note

Also published as: WO2015185067 (A9) AU2015271324 (A1) CA2951325 (A1) EP3152232 (A1) JP2017518375 (A) SG11201610177U (A) US2017343545 (A1)

Cite this

Reker Hadrup, S., Pedersen, H., Jakobsen, S., & Bentzen, A. K. (2015). IPC No. G01N 33/ 569 A I. Determining antigen recognition through barcoding of mhc multimers. (Patent No. WO2015185067).