Determination of radionuclidic impurities in 99mTceluate from 99Mo/99mTc generator for quality control

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    Abstract

    Technetium-99m is the principal radioisotope used in medical diagnostics; radionuclidic impurity is the major concern of its quality. This work presents a analytical method for sequential determination of all radionuclidic impurities listed in pharmacopoeia including gamma emitters, alpha emitters, 89Sr and 90Sr. Radioactive decay for removal of 99mTc, ion exchange and extraction chromatography for removal of 99Mo and 99Tc are effective for separation of interferences. Gamma spectrometry, LSC with alpha/beta discrimination, and Cherenkov counting using LSC are sensitive methods for measurement of the impurity radionuclides. The detection limits of this method are well meet the requirement of the quality control according to the limitation of the pharmacopoeia.
    Original languageEnglish
    JournalJournal of Radioanalytical and Nuclear Chemistry
    Volume314
    Issue number2
    Pages (from-to)659-668
    ISSN0236-5731
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Radionuclidic impurity
    • Mo-99/Tc-99m generator
    • Ion exchange
    • Extraction chromatography
    • Liquid scintillation counting
    • Alpha-beta discrimination
    • Cherenkov counting

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