Determination of radionuclidic impurities in 99mTceluate from 99Mo/99mTc generator for quality control

Xiaolin Hou

doi:10.1007/s10967-017-5369-9

Determination of radionuclidic impurities in ^99mTceluate from ⁹⁹Mo/^99mTc generator for quality control

Xiaolin Hou

Research output: Contribution to journal › Journal article › Research › peer-review

365 Downloads (Pure)

Abstract

Technetium-99m is the principal radioisotope used in medical diagnostics; radionuclidic impurity is the major concern of its quality. This work presents a analytical method for sequential determination of all radionuclidic impurities listed in pharmacopoeia including gamma emitters, alpha emitters, ⁸⁹Sr and ⁹⁰Sr. Radioactive decay for removal of ^99mTc, ion exchange and extraction chromatography for removal of ⁹⁹Mo and ⁹⁹Tc are effective for separation of interferences. Gamma spectrometry, LSC with alpha/beta discrimination, and Cherenkov counting using LSC are sensitive methods for measurement of the impurity radionuclides. The detection limits of this method are well meet the requirement of the quality control according to the limitation of the pharmacopoeia.

Original language	English
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	314
Issue number	2
Pages (from-to)	659-668
ISSN	0236-5731
DOIs	https://doi.org/10.1007/s10967-017-5369-9
Publication status	Published - 2017

Keywords

Radionuclidic impurity
Mo-99/Tc-99m generator
Ion exchange
Extraction chromatography
Liquid scintillation counting
Alpha-beta discrimination
Cherenkov counting

Access to Document

10.1007/s10967-017-5369-9

Post print Determination of impurities in 99mTc eluate JRNC 2017Accepted author manuscript, 535 KB

OpenUrl availability

Full text

Cite this

@article{45b872322b9d418ebc77ab3f445d334b,

title = "Determination of radionuclidic impurities in 99mTceluate from 99Mo/99mTc generator for quality control",

abstract = "Technetium-99m is the principal radioisotope used in medical diagnostics; radionuclidic impurity is the major concern of its quality. This work presents a analytical method for sequential determination of all radionuclidic impurities listed in pharmacopoeia including gamma emitters, alpha emitters, 89Sr and 90Sr. Radioactive decay for removal of 99mTc, ion exchange and extraction chromatography for removal of 99Mo and 99Tc are effective for separation of interferences. Gamma spectrometry, LSC with alpha/beta discrimination, and Cherenkov counting using LSC are sensitive methods for measurement of the impurity radionuclides. The detection limits of this method are well meet the requirement of the quality control according to the limitation of the pharmacopoeia.",

keywords = "Radionuclidic impurity, Mo-99/Tc-99m generator, Ion exchange, Extraction chromatography, Liquid scintillation counting, Alpha-beta discrimination, Cherenkov counting",

author = "Xiaolin Hou",

year = "2017",

doi = "10.1007/s10967-017-5369-9",

language = "English",

volume = "314",

pages = "659--668",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Akademiai Kiado Rt.",

number = "2",

}

TY - JOUR

T1 - Determination of radionuclidic impurities in 99mTceluate from 99Mo/99mTc generator for quality control

AU - Hou, Xiaolin

PY - 2017

Y1 - 2017

N2 - Technetium-99m is the principal radioisotope used in medical diagnostics; radionuclidic impurity is the major concern of its quality. This work presents a analytical method for sequential determination of all radionuclidic impurities listed in pharmacopoeia including gamma emitters, alpha emitters, 89Sr and 90Sr. Radioactive decay for removal of 99mTc, ion exchange and extraction chromatography for removal of 99Mo and 99Tc are effective for separation of interferences. Gamma spectrometry, LSC with alpha/beta discrimination, and Cherenkov counting using LSC are sensitive methods for measurement of the impurity radionuclides. The detection limits of this method are well meet the requirement of the quality control according to the limitation of the pharmacopoeia.

AB - Technetium-99m is the principal radioisotope used in medical diagnostics; radionuclidic impurity is the major concern of its quality. This work presents a analytical method for sequential determination of all radionuclidic impurities listed in pharmacopoeia including gamma emitters, alpha emitters, 89Sr and 90Sr. Radioactive decay for removal of 99mTc, ion exchange and extraction chromatography for removal of 99Mo and 99Tc are effective for separation of interferences. Gamma spectrometry, LSC with alpha/beta discrimination, and Cherenkov counting using LSC are sensitive methods for measurement of the impurity radionuclides. The detection limits of this method are well meet the requirement of the quality control according to the limitation of the pharmacopoeia.

KW - Radionuclidic impurity

KW - Mo-99/Tc-99m generator

KW - Ion exchange

KW - Extraction chromatography

KW - Liquid scintillation counting

KW - Alpha-beta discrimination

KW - Cherenkov counting

U2 - 10.1007/s10967-017-5369-9

DO - 10.1007/s10967-017-5369-9

M3 - Journal article

SN - 0236-5731

VL - 314

SP - 659

EP - 668

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -