Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains

Bent O. Petersen; Sebastian Meier; Berit Smestad Paulsen; Antonio R. Redondo; Ian C. Skovsted

doi:10.1016/j.carres.2014.06.018

Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains

Bent O. Petersen, Sebastian Meier, Berit Smestad Paulsen, Antonio R. Redondo, Ian C. Skovsted

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Abstract

The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesis
have been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete. Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42 and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be defined in this manner.

Original language	English
Journal	Carbohydrate Research
ISSN	0008-6215
DOIs	https://doi.org/10.1016/j.carres.2014.06.018
Publication status	Published - 2014
Externally published	Yes

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CAR D 14 00315R1 3Submitted manuscript, 2.88 MB

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title = "Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains",

abstract = "The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesishave been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete. Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42 and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be defined in this manner. ",

author = "Petersen, {Bent O.} and Sebastian Meier and Paulsen, {Berit Smestad} and Redondo, {Antonio R.} and Skovsted, {Ian C.}",

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doi = "10.1016/j.carres.2014.06.018",

language = "English",

journal = "Carbohydrate Research",

issn = "0008-6215",

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T1 - Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains

AU - Petersen, Bent O.

AU - Meier, Sebastian

AU - Paulsen, Berit Smestad

AU - Redondo, Antonio R.

AU - Skovsted, Ian C.

PY - 2014

Y1 - 2014

N2 - The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesishave been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete. Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42 and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be defined in this manner.

AB - The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesishave been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete. Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42 and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be defined in this manner.

U2 - 10.1016/j.carres.2014.06.018

DO - 10.1016/j.carres.2014.06.018

M3 - Journal article

C2 - 25036733

SN - 0008-6215

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains

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