Determination of native capsular polysaccharide structures of Steptococcus pneumoniae serotypes 39, 42 and 47F and comparison to genetically or serologically related strains

Bent O. Petersen, Sebastian Meier, Berit Smestad Paulsen, Antonio R. Redondo, Ian C. Skovsted

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Abstract

The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesis
have been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete. Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42 and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be defined in this manner.
Original languageEnglish
JournalCARBOHYDRATE RESEARCH
ISSN0008-6215
DOIs
Publication statusPublished - 2014
Externally publishedYes

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