Detection and classification of parasite eggs for use in helminthic therapy

Johan Musaeus Bruun, Christian M. O. Kapel, Jens Michael Carstensen

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    Eggs from the small, intestinal pig whipworm Trichuris suis constitute the active pharmaceutical ingredient in a novel type of medicine for chronic autoimmune diseases like Crohn's disease. The pharmaceutical potency of such an egg suspension can be assessed by microscopic inspection, as only eggs containing a viable, infective larva provoke the wanted immune reaction. Thus, a precise and objective estimate of the concentration of infective eggs is crucial for dosing the new medicine. In this paper, a vision-based method for detecting and classifying T. suis parasite eggs is described. The detection is based on matched filters and the classification is done using linear and quadratic discriminant analysis on a set of biologically inspired features, including the autocorrelation-based longitudinal anisotropy and the mean scattering intensity under dark field illumination. Despite the presence of impurities and overlapping eggs, the proposed method achieves cross-validated classification rates around 93%.
    Original languageEnglish
    Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)
    PublisherIEEE
    Publication date2012
    Pages1627-1630
    ISBN (Print)978-1-4577-1857-1
    DOIs
    Publication statusPublished - 2012
    Event9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Barcelona, Spain
    Duration: 2 May 20125 May 2012
    http://www.biomedicalimaging.org/2012/
    https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=17944

    Conference

    Conference9th IEEE International Symposium on Biomedical Imaging
    Country/TerritorySpain
    CityBarcelona
    Period02/05/201205/05/2012
    Internet address

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