Abstract
γ-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first 125I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
Original language | English |
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Journal | Journal of Medicinal Chemistry |
Volume | 53 |
Issue number | 17 |
Pages (from-to) | 6506-6510 |
ISSN | 0022-2623 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Hevesy laboratory
- Radiation research and nuclear technologies