Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Biological Activity 100%
• Hydrogen Bond 50%
• Conformation 50%
• N-Terminus 50%
• Blood Coagulation Factor 50%
• C-Terminus 50%
• Serine Protease 50%
• Tripeptide 50%
• Thrombin 50%
• Haemophilia A 50%
• Haemophilia B 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Biological Activity 100%
• Amino Acid 100%
• Hydrogen Bond 50%
• Serine Proteinase 50%
• Blood Clotting Factor 50%
• Thrombin 50%
• Haemophilia B 50%
• Haemophilia A 50%
• Tripeptide 50%

Keyphrases

• Desolvation 33%
• Intramolecular Hydrogen Bond 33%
• Recombinant Activated Factor VII (rFVIIa) 33%