Design of microfluidic bioreactors using topology optimization

Fridolin Okkels, Henrik Bruus

    Research output: Contribution to journalJournal articleResearchpeer-review


    We address the design of optimal reactors for supporting biological cultures using the method of topology optimization. For some years this method have been used to design various optimal microfluidic devices.1-4 We apply this method to distribute optimally biologic cultures within a flow of nutrition. From this optimized distribution alone the metabolic rate in the reactor increase by close to a factor 20.
    Original languageEnglish
    JournalJournal of Computational and Theoretical Nanoscience
    Issue number4
    Pages (from-to)814-816
    Publication statusPublished - 2007


    • Microfluidics
    • Bio-reactors
    • Topology optimization

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