Design of microfluidic bioreactors using topology optimization

Fridolin Okkels, Henrik Bruus

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    We address the design of optimal reactors for supporting biological cultures using the method of topology optimization. For some years this method have been used to design various optimal microfluidic devices.1-4 We apply this method to distribute optimally biologic cultures within a flow of nutrition. From this optimized distribution alone the metabolic rate in the reactor increase by close to a factor 20.
    Original languageEnglish
    JournalJournal of Computational and Theoretical Nanoscience
    Volume4
    Issue number4
    Pages (from-to)814-816
    ISSN1546-1955
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Microfluidics
    • Bio-reactors
    • Topology optimization

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