Design of Fab-based chimeric antibodies against Bothrops asper toxins

Aleksander M. Haack; Malte B. Hallgren; Rasmus U. W. Friis; Søren H. Dam; Andrea Martos Esteban; Mikael Rørdam Andersen; Mogens Kilstrup; Andreas Hougaard Laustsen

Design of Fab-based chimeric antibodies against Bothrops asper toxins

Aleksander M. Haack, Malte B. Hallgren, Rasmus U. W. Friis, Søren H. Dam, Andrea Martos Esteban, Mikael Rørdam Andersen, Mogens Kilstrup, Andreas Hougaard Laustsen

Technical University of Denmark

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Abstract

Snakebite is one of the world’s most neglected tropical diseases, with an estimated 5 million bites per year, resulting in about 125.000 deaths. The only current treatment for snakebite envenoming is antiserum derived from the blood of immunized mammals(typically horses). These antisera are expensive to produce and carry a high risk of causing hyper-allergic reactions in human recipients due to their heterologous origin. Here we report the discovery of chimeric scFvs against Bothrops asper toxins.

Original language	English
Publication date	2016
Number of pages	1
Publication status	Published - 2016
Event	Symposium for Biological and Life Science Students 2016 - Cambridge, United Kingdom Duration: 25 Nov 2016 → 25 Nov 2016

Conference

Conference	Symposium for Biological and Life Science Students 2016
Country/Territory	United Kingdom
City	Cambridge
Period	25/11/2016 → 25/11/2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Design of Fab-based chimeric antibodies against Bothrops asper toxins",

abstract = "Snakebite is one of the world{\textquoteright}s most neglected tropical diseases, with an estimated 5 million bites per year, resulting in about 125.000 deaths. The only current treatment for snakebite envenoming is antiserum derived from the blood of immunized mammals(typically horses). These antisera are expensive to produce and carry a high risk of causing hyper-allergic reactions in human recipients due to their heterologous origin. Here we report the discovery of chimeric scFvs against Bothrops asper toxins.",

author = "{M. Haack}, Aleksander and {B. Hallgren}, Malte and {U. W. Friis}, Rasmus and {H. Dam}, S{\o}ren and {Martos Esteban}, Andrea and Andersen, {Mikael R{\o}rdam} and Mogens Kilstrup and Laustsen, {Andreas Hougaard}",

year = "2016",

language = "English",

note = "Symposium for Biological and Life Science Students 2016, SymBLS ; Conference date: 25-11-2016 Through 25-11-2016",

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TY - CONF

T1 - Design of Fab-based chimeric antibodies against Bothrops asper toxins

AU - M. Haack, Aleksander

AU - B. Hallgren, Malte

AU - U. W. Friis, Rasmus

AU - H. Dam, Søren

AU - Martos Esteban, Andrea

AU - Andersen, Mikael Rørdam

AU - Kilstrup, Mogens

AU - Laustsen, Andreas Hougaard

PY - 2016

Y1 - 2016

N2 - Snakebite is one of the world’s most neglected tropical diseases, with an estimated 5 million bites per year, resulting in about 125.000 deaths. The only current treatment for snakebite envenoming is antiserum derived from the blood of immunized mammals(typically horses). These antisera are expensive to produce and carry a high risk of causing hyper-allergic reactions in human recipients due to their heterologous origin. Here we report the discovery of chimeric scFvs against Bothrops asper toxins.

AB - Snakebite is one of the world’s most neglected tropical diseases, with an estimated 5 million bites per year, resulting in about 125.000 deaths. The only current treatment for snakebite envenoming is antiserum derived from the blood of immunized mammals(typically horses). These antisera are expensive to produce and carry a high risk of causing hyper-allergic reactions in human recipients due to their heterologous origin. Here we report the discovery of chimeric scFvs against Bothrops asper toxins.

M3 - Poster

T2 - Symposium for Biological and Life Science Students 2016

Y2 - 25 November 2016 through 25 November 2016

ER -

Design of Fab-based chimeric antibodies against Bothrops asper toxins

Abstract

Conference

UN SDGs

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