Design of Fab-based chimeric antibodies against Bothrops asper toxins

Aleksander M. Haack, Malte B. Hallgren, Rasmus U. W. Friis, Søren H. Dam, Andrea Martos Esteban, Mikael Rørdam Andersen, Mogens Kilstrup, Andreas Hougaard Laustsen

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    Abstract

    Snakebite is one of the world’s most neglected tropical diseases, with an estimated 5 million bites per year, resulting in about 125.000 deaths. The only current treatment for snakebite envenoming is antiserum derived from the blood of immunized mammals(typically horses). These antisera are expensive to produce and carry a high risk of causing hyper-allergic reactions in human recipients due to their heterologous origin. Here we report the discovery of chimeric scFvs against Bothrops asper toxins.
    Original languageEnglish
    Publication date2016
    Number of pages1
    Publication statusPublished - 2016
    EventSymposium for Biological and Life Science Students (SymBLS) 2016 - Cambridge, United Kingdom
    Duration: 25 Nov 201625 Nov 2016

    Conference

    ConferenceSymposium for Biological and Life Science Students (SymBLS) 2016
    CountryUnited Kingdom
    CityCambridge
    Period25/11/201625/11/2016

    Cite this

    M. Haack, A., B. Hallgren, M., U. W. Friis, R., H. Dam, S., Martos Esteban, A., Andersen, M. R., Kilstrup, M., & Laustsen, A. H. (2016). Design of Fab-based chimeric antibodies against Bothrops asper toxins. Poster session presented at Symposium for Biological and Life Science Students (SymBLS) 2016, Cambridge, United Kingdom.