Design of enzymatic cascade processes for the production of low-priced chemicals

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review


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While the application of enzymes to synthetic and industrial problems continues to grow, the major development today is focused on multi-enzymatic cascades. Such systems are particularly attractive, because many commercially available enzymes operate under relatively similar operating conditions. This opens the possibility of one-pot operation with multiple enzymes in a single reactor. In this paper the concept of modules is introduced whereby groups of enzymes are combined in modules, each operating in a single reactor, but with the option of various operating strategies to avoid any complications of nonproductive interactions between the enzymes, substrates or products in a given reactor. In this paper the selection of modules is illustrated using the synthesis of the bulk chemical, gluconic acid, from lignocellulosic waste.
Original languageEnglish
JournalZeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Issue number3-4
Pages (from-to)77-84
Number of pages8
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Biocatalyst, Biocatalytic reactions, Multi-enzymatic cascade, Reaction modules
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ID: 167240972