Design of a process template for amine synthesis

Ravendra Singh, Andy Godfrey, Björn Gregertsen, Frans Muller, Bhanu Vankayala, Katja Haas-Santo, Krist Gernaey, Rafiqul Gani, John Woodley

Research output: Book/ReportReportpeer-review

Abstract

A conceptual nitro reduction process template that should be generic such that it can handle a series of substrates with sim ilar molecular functionality has been designed. The reduction process is based on a continuo us plug-flow slurry reactor. The process template aims at speeding up the process development for new substrates by being easily adapted for a range of substrates as well as easily scaled by numbering-up. The potential saving in process development time could make it a particularly powerful experimental tool for early delivery campaigns in the pharmaceutical industry for the production of Kg amounts of material for clinical trials.
Original languageEnglish
PublisherTechnical University of Denmark, Department of Chemical and Biochemical Engineering
Number of pages26
Publication statusPublished - 2015
SeriesCAPEC-PROCESS Report

Keywords

  • Generic proces
  • Nitro reduction
  • Process template
  • Substrate adoption methodology
  • Fast process development
  • Flexible process
  • Pharmaceutical manufacturing process

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