Design of a New SO2-Surrogate and Its Applications in Palladium-Catalyzed Direct Aminosulfonylations between Aryl Iodides and Amines

Zhong Lian*, Xiuwen Jia, Søren Kramer, Troels Skrydstrup

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A new SO 2 -surrogate is reported which is cheap, bench-stable, and can be accessed in just two steps from bulk chemicals. Essentially complete SO 2 -release is achieved in 5 minutes. Eight established sulfonylation reactions proceeded smoothly by ex-situ formation of SO 2 utilizing a two-chamber system in combination with the SO 2 -surrogate. Furthermore, we report the first direct aminosulfonylation between aryl iodides and amines. Broad functional group tolerance is demonstrated, and the method is applicable to pharmaceutically relevant substrates, including heterocyclic substrates.

Original languageEnglish
JournalAngewandte Chemie International Edition
Volume60
Issue number13
Pages (from-to)7353-7359
ISSN1433-7851
DOIs
Publication statusPublished - 2021

Bibliographical note

© 2020 Wiley-VCH GmbH.

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