Dermal Uptake of Benzophenone-3 from Clothing

Glenn C. Morrison, Gabriel Bekö, Charles J. Weschler, Tobias Schripp, Tunga Salthammer, Jonathan Hill, Anna-Maria Andersson, Jørn Toftum, Geo Clausen, Hanne Frederiksen

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    Abstract

    Benzophenone-3 (also known as BP-3 or oxybenzone) is added to sunscreens, plastics, and some coatings to filter UV radiation. The suspected endocrine disruptor BP-3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. Given its physical and chemical properties, we hypothesized that dermal uptake from clothing could contribute to the body burden of this compound. First, cotton shirts were exposed to air at an elevated concentration of BP-3 for 32 days; the final air concentration was 4.4 μg/m3. Next, three participants wore the exposed shirts for 3 h. After 3 h of exposure, participants wore their usual clothing during the collection of urine samples for the next 48 h. Urine was analyzed for BP-3, a metabolite (BP-1), and six other UV filters. The rate of urinary excretion of the sum of BP-1 and BP-3 increased for all participants during and following the 3 h of exposure. The summed mass of BP-1 and BP-3 excreted during the first 24 h attributable to wearing exposed t-shirts were 12, 9.9, and 82μg for participants 1, 2, and 3, respectively. Analysis of these results, coupled with predictions of steady-state models, suggest that dermal uptake of BP-3 from clothing could meaningfully contribute to overall body burden.
    Original languageEnglish
    JournalEnvironmental Science and Technology
    Volume51
    Issue number19
    Pages (from-to)11371-11379
    Number of pages9
    ISSN0013-936X
    DOIs
    Publication statusPublished - 2017

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