Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction

Michael Sandrini, Jure Piskur

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.
    Original languageEnglish
    JournalTrends in Biochemical Sciences
    Volume30
    Issue number5
    Pages (from-to)225-228
    ISSN0968-0004
    Publication statusPublished - 2005

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