Abstract
Bedside diagnosis of skin cancer remains a challenging task. The real-time non-invasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results. This article is protected by copyright.
Original language | English |
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Article number | e202100083 |
Journal | journal of biophotonics |
Volume | 14 |
Issue number | 11 |
Number of pages | 20 |
ISSN | 1864-063X |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Angiography
- Basal cell carcinoma
- BCC
- OCT
- Optical coherence tomography
- Papillary dermis
- Ultrahigh resolution
- Upper dermis