Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography - a pilot study

Niels Møller Israelsen*, Mette Mogensen, Mikkel Jensen, Merete Haedersdal, Ole Bang

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Bedside diagnosis of skin cancer remains a challenging task. The real-time non-invasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results. This article is protected by copyright. All rights reserved.
Original languageEnglish
Article numbere202100083
Journaljournal of biophotonics
Number of pages20
ISSN1864-063X
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Angiography
  • Basal cell carcinoma
  • BCC
  • OCT
  • Optical coherence tomography
  • Papillary dermis
  • Ultrahigh resolution
  • Upper dermis

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