Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography - a pilot study

Niels Møller Israelsen*, Mette Mogensen, Mikkel Jensen, Merete Haedersdal, Ole Bang

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Bedside diagnosis of skin cancer remains a challenging task. The real-time non-invasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results. This article is protected by copyright.
    Original languageEnglish
    Article numbere202100083
    Journaljournal of biophotonics
    Volume14
    Issue number11
    Number of pages20
    ISSN1864-063X
    DOIs
    Publication statusPublished - 2021

    Keywords

    • Angiography
    • Basal cell carcinoma
    • BCC
    • OCT
    • Optical coherence tomography
    • Papillary dermis
    • Ultrahigh resolution
    • Upper dermis

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