Degradation studies of hydrophilic, partially degradable and bioactive cements (HDBCs) incorporating chemically modified starch

Ana Carina Loureiro Mendes, Luciano F. Boesel, Rui L. Reis

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The degradation rate in Hydrophilic, Degradable and Bioactive Cements (HDBCs) containing starch/cellulose acetate blends (SCA) is still low. In order to increase degradation, higher amounts of starch are required to exceed the percolation threshold. In this work, gelatinization, acetylation and methacrylation of corn starch were performed and assessed as candidates to replace SCA in HDBCs. Formulations containing methacrylated starch were prepared with different molar ratios of 2-hydroxyethyl methacrylate and methyl methacrylate in the liquid component and the amount of residual monomer released into water was evaluated. The concentration of reducing sugars, percentage of weight loss and morphologic analyses after degradation all confirmed increased degradation of HDBC with alpha-amylase, with the appearance of pores and voids from enzymatic action. Methacrylated starch therefore is a better alternative to be used as the solid component of HDBC then SCA, since it leads to the formation of cements with a lower release of toxic monomers and more prone to hydrolytic degradation while keeping the other advantages of HDBCs.
Original languageEnglish
JournalJournal of Materials Science: Materials in Medicine
Volume23
Issue number3
Pages (from-to)667-676
Number of pages10
ISSN0957-4530
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Acetylation
  • Cements
  • Esters
  • Gelation
  • Hydrophilicity
  • Monomers
  • Starch
  • Sugars
  • Degradation
  • 2 hydroxyethyl methacrylate
  • amylase
  • cellulose acetate
  • cement
  • methacrylic acid methyl ester
  • monomer
  • starch
  • water
  • gelatin
  • methacrylic acid derivative
  • acetylation
  • article
  • biological activity
  • chemical composition
  • chemical modification
  • degradation kinetics
  • enzyme activity
  • gelatinization
  • hydrophilicity
  • liquid
  • morphology
  • priority journal
  • proton nuclear magnetic resonance
  • structure analysis
  • substitution reaction
  • temperature
  • chemistry
  • infrared spectroscopy
  • nuclear magnetic resonance spectroscopy
  • scanning electron microscopy
  • Zea mays
  • Gelatin
  • Magnetic Resonance Spectroscopy
  • Methacrylates
  • Microscopy, Electron, Scanning
  • Spectroscopy, Fourier Transform Infrared
  • 2-hydroxyethyl methacrylate
  • Cellulose acetates
  • Chemically modified
  • Corn starch
  • Degradation rate
  • Degradation study
  • Enzymatic action
  • Hydrolytic degradation
  • Liquid components
  • Methacrylation
  • Methyl methacrylates
  • Molar ratio
  • Morphologic analysis
  • Percolation thresholds
  • Reducing sugars
  • Residual monomers
  • Solid components
  • Weight loss
  • 6E1I4IV47V hydroxyethyl methacrylate
  • 9000-70-8 Gelatin
  • 9005-25-8 Starch
  • ENGINEERING,
  • MATERIALS
  • BONE CEMENTS
  • MECHANICAL-PROPERTIES
  • ENZYMATIC DEGRADATION
  • GELATINIZATION
  • BEHAVIOR
  • BIOMATERIALS
  • COMPOSITES
  • HYDROGELS
  • BLENDS
  • WATER

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