Abstract
beta-Keto carboxylic acids are known to decarboxylate readily. In our pursuit to synthesize beta-indolinyl propiophenones, we have exploited this chemistry as a mean of establishing a traceless handle. 2-Aroyl acrylic acids have been esterified to a trityl resin, after which Michael-type addition of indolines have been performed. Upon cleavage, the products are decarboxylated, and the beta-indolinyl propiophenones are isolated. The reaction conditions have been optimized, and a small library has been prepared. (C) 1998 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Journal | Tetrahedron Letters |
Volume | 39 |
Issue number | 15 |
Pages (from-to) | 2207-2210 |
ISSN | 0040-4039 |
DOIs | |
Publication status | Published - 1998 |