Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

S. P. Lund, L. Simonsen, Ulla Hass, Ole Ladefoged, Henrik Rye Lam, G. Ostergaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Dearomatized white spirit inhalation exposure causes long-lasting neurophysioloical changes in rats. NEUROTOXICOL TERATOL 18(1), 67-76, 1996. -Exposure for 6 h per day, 5 days per week, during a period of 6 months to the organic solvent dearomatized white spirit (0, 400, and 800 ppm) was studied in rats that were 3 months old when the repeated exposure was initiated. After an exposure-free period of 2-6 months duration, neurophysiological, neurobehavioral, and macroscopic pathologic examinations were performed. The study revealed exposure-related changes in sensory evoked potentials and a decrease in motor activity during dark (no light) periods but no white spirit-induced changes in learning and memory functions. The measurements of the flash evoked potential (FEP), somatosensory evoked potential (SEP), and auditory brain stem response (ABR) all demonstrated dose-dependent increases of the amplitudes of the early latency peaks of the sensory evoked potentials (EPs). Furthermore, an increase of the dose showed that the measurements of FEP and SEP revealed changes in the later-latency peaks, which reflect the more associative aspects of sensory processing. The results demonstrated that 6 months of exposure to dearomatized white spirit induced long-lasting and possible irreversible effects in the nervous system of the rat.
Original languageEnglish
JournalNeurotoxicology and Teratology
Volume18
Issue number1
Pages (from-to)67-76
ISSN0892-0362
DOIs
Publication statusPublished - 1996

Keywords

  • aliphatic hydrocarbon
  • Exxsol D 40
  • 64742-48-9
  • Stoddard solvent
  • organic solvent
  • toxic encephalopathy
  • sensory evoked potentials
  • behavior

Cite this

Lund, S. P. ; Simonsen, L. ; Hass, Ulla ; Ladefoged, Ole ; Lam, Henrik Rye ; Ostergaard, G. / Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats. In: Neurotoxicology and Teratology. 1996 ; Vol. 18, No. 1. pp. 67-76.
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title = "Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats",
abstract = "Dearomatized white spirit inhalation exposure causes long-lasting neurophysioloical changes in rats. NEUROTOXICOL TERATOL 18(1), 67-76, 1996. -Exposure for 6 h per day, 5 days per week, during a period of 6 months to the organic solvent dearomatized white spirit (0, 400, and 800 ppm) was studied in rats that were 3 months old when the repeated exposure was initiated. After an exposure-free period of 2-6 months duration, neurophysiological, neurobehavioral, and macroscopic pathologic examinations were performed. The study revealed exposure-related changes in sensory evoked potentials and a decrease in motor activity during dark (no light) periods but no white spirit-induced changes in learning and memory functions. The measurements of the flash evoked potential (FEP), somatosensory evoked potential (SEP), and auditory brain stem response (ABR) all demonstrated dose-dependent increases of the amplitudes of the early latency peaks of the sensory evoked potentials (EPs). Furthermore, an increase of the dose showed that the measurements of FEP and SEP revealed changes in the later-latency peaks, which reflect the more associative aspects of sensory processing. The results demonstrated that 6 months of exposure to dearomatized white spirit induced long-lasting and possible irreversible effects in the nervous system of the rat.",
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author = "Lund, {S. P.} and L. Simonsen and Ulla Hass and Ole Ladefoged and Lam, {Henrik Rye} and G. Ostergaard",
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Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats. / Lund, S. P.; Simonsen, L.; Hass, Ulla; Ladefoged, Ole; Lam, Henrik Rye; Ostergaard, G.

In: Neurotoxicology and Teratology, Vol. 18, No. 1, 1996, p. 67-76.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

AU - Lund, S. P.

AU - Simonsen, L.

AU - Hass, Ulla

AU - Ladefoged, Ole

AU - Lam, Henrik Rye

AU - Ostergaard, G.

PY - 1996

Y1 - 1996

N2 - Dearomatized white spirit inhalation exposure causes long-lasting neurophysioloical changes in rats. NEUROTOXICOL TERATOL 18(1), 67-76, 1996. -Exposure for 6 h per day, 5 days per week, during a period of 6 months to the organic solvent dearomatized white spirit (0, 400, and 800 ppm) was studied in rats that were 3 months old when the repeated exposure was initiated. After an exposure-free period of 2-6 months duration, neurophysiological, neurobehavioral, and macroscopic pathologic examinations were performed. The study revealed exposure-related changes in sensory evoked potentials and a decrease in motor activity during dark (no light) periods but no white spirit-induced changes in learning and memory functions. The measurements of the flash evoked potential (FEP), somatosensory evoked potential (SEP), and auditory brain stem response (ABR) all demonstrated dose-dependent increases of the amplitudes of the early latency peaks of the sensory evoked potentials (EPs). Furthermore, an increase of the dose showed that the measurements of FEP and SEP revealed changes in the later-latency peaks, which reflect the more associative aspects of sensory processing. The results demonstrated that 6 months of exposure to dearomatized white spirit induced long-lasting and possible irreversible effects in the nervous system of the rat.

AB - Dearomatized white spirit inhalation exposure causes long-lasting neurophysioloical changes in rats. NEUROTOXICOL TERATOL 18(1), 67-76, 1996. -Exposure for 6 h per day, 5 days per week, during a period of 6 months to the organic solvent dearomatized white spirit (0, 400, and 800 ppm) was studied in rats that were 3 months old when the repeated exposure was initiated. After an exposure-free period of 2-6 months duration, neurophysiological, neurobehavioral, and macroscopic pathologic examinations were performed. The study revealed exposure-related changes in sensory evoked potentials and a decrease in motor activity during dark (no light) periods but no white spirit-induced changes in learning and memory functions. The measurements of the flash evoked potential (FEP), somatosensory evoked potential (SEP), and auditory brain stem response (ABR) all demonstrated dose-dependent increases of the amplitudes of the early latency peaks of the sensory evoked potentials (EPs). Furthermore, an increase of the dose showed that the measurements of FEP and SEP revealed changes in the later-latency peaks, which reflect the more associative aspects of sensory processing. The results demonstrated that 6 months of exposure to dearomatized white spirit induced long-lasting and possible irreversible effects in the nervous system of the rat.

KW - aliphatic hydrocarbon

KW - Exxsol D 40

KW - 64742-48-9

KW - Stoddard solvent

KW - organic solvent

KW - toxic encephalopathy

KW - sensory evoked potentials

KW - behavior

U2 - 10.1016/0892-0362(95)02014-4

DO - 10.1016/0892-0362(95)02014-4

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JO - Neurotoxicology and Teratology

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SN - 0892-0362

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