Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum

Ling Ding; Hans-Martin Dahse; Christian Hertweck

doi:10.1021/np2008544

Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum

Ling Ding, Hans-Martin Dahse, Christian Hertweck

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.

Original language	English
Journal	Journal of Natural Products
Volume	75
Issue number	4
Pages (from-to)	617-621
Number of pages	5
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np2008544
Publication status	Published - 2012
Externally published	Yes

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title = "Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum",

abstract = "Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.",

author = "Ling Ding and Hans-Martin Dahse and Christian Hertweck",

year = "2012",

doi = "10.1021/np2008544",

language = "English",

volume = "75",

pages = "617--621",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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T1 - Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum

AU - Ding, Ling

AU - Dahse, Hans-Martin

AU - Hertweck, Christian

PY - 2012

Y1 - 2012

N2 - Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.

AB - Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.

U2 - 10.1021/np2008544

DO - 10.1021/np2008544

M3 - Journal article

SN - 0163-3864

VL - 75

SP - 617

EP - 621

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum

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