Cytokine profile of Armenian patients with Familial Mediterranean fever

G.P. Manukyan; K.A. Ghazaryan; Zh. A. Ktsoyan; M.V. Tatyan; Z.A. Khachatryan; G.S. Hakobyan; V.A. Mkrtchyan; D. Kelly; A. Coutts; R.I. Aminov

doi:10.1016/j.clinbiochem.2008.03.017

Cytokine profile of Armenian patients with Familial Mediterranean fever

G.P. Manukyan, K.A. Ghazaryan, Zh. A. Ktsoyan, M.V. Tatyan, Z.A. Khachatryan, G.S. Hakobyan, V.A. Mkrtchyan, D. Kelly, A. Coutts, R.I. Aminov

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
Conclusions: Inflammation in FNIF involves Treg and Th17 lineages.

Original language	English
Journal	Clinical Biochemistry
Volume	41
Issue number	10-11
Pages (from-to)	920-922
Number of pages	3
ISSN	0009-9120
DOIs	https://doi.org/10.1016/j.clinbiochem.2008.03.017
Publication status	Published - 2008
Externally published	Yes

Keywords

Familial Mediterranean fever
Sera
ELISA
CBA
Cytokines

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10.1016/j.clinbiochem.2008.03.017

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title = "Cytokine profile of Armenian patients with Familial Mediterranean fever",

abstract = "Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. Conclusions: Inflammation in FNIF involves Treg and Th17 lineages.",

keywords = "Familial Mediterranean fever, Sera, ELISA, CBA, Cytokines",

author = "G.P. Manukyan and K.A. Ghazaryan and Ktsoyan, {Zh. A.} and M.V. Tatyan and Z.A. Khachatryan and G.S. Hakobyan and V.A. Mkrtchyan and D. Kelly and A. Coutts and R.I. Aminov",

year = "2008",

doi = "10.1016/j.clinbiochem.2008.03.017",

language = "English",

volume = "41",

pages = "920--922",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier",

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TY - JOUR

T1 - Cytokine profile of Armenian patients with Familial Mediterranean fever

AU - Manukyan, G.P.

AU - Ghazaryan, K.A.

AU - Ktsoyan, Zh. A.

AU - Tatyan, M.V.

AU - Khachatryan, Z.A.

AU - Hakobyan, G.S.

AU - Mkrtchyan, V.A.

AU - Kelly, D.

AU - Coutts, A.

AU - Aminov, R.I.

PY - 2008

Y1 - 2008

N2 - Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. Conclusions: Inflammation in FNIF involves Treg and Th17 lineages.

AB - Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. Conclusions: Inflammation in FNIF involves Treg and Th17 lineages.

KW - Familial Mediterranean fever

KW - Sera

KW - ELISA

KW - CBA

KW - Cytokines

U2 - 10.1016/j.clinbiochem.2008.03.017

DO - 10.1016/j.clinbiochem.2008.03.017

M3 - Journal article

SN - 0009-9120

VL - 41

SP - 920

EP - 922

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 10-11

ER -

Cytokine profile of Armenian patients with Familial Mediterranean fever

Abstract

Keywords

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