Cytokine profile of Armenian patients with Familial Mediterranean fever

G.P. Manukyan, K.A. Ghazaryan, Zh. A. Ktsoyan, M.V. Tatyan, Z.A. Khachatryan, G.S. Hakobyan, V.A. Mkrtchyan, D. Kelly, A. Coutts, R.I. Aminov

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
Conclusions: Inflammation in FNIF involves Treg and Th17 lineages.
Original languageEnglish
JournalClinical Biochemistry
Volume41
Issue number10-11
Pages (from-to)920-922
Number of pages3
ISSN0009-9120
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Familial Mediterranean fever
  • Sera
  • ELISA
  • CBA
  • Cytokines

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