Cyprus Women's Health Research (COHERE) initiative

Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population

M. B. Hocaoglu, S. Gurkas, T. Karaderi, B. Taneri, K. Erguler, B. Barin, E. M. Bilgin, G. Eralp, M. Allison, N. Findikli, K. Boynukalin, M. Bahceci, H. Naci, K. Vincent, S. A. Missmer, C. M. Becker, K. T. Zondervan, N. Rahmioglu*

*Corresponding author for this work

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Abstract

Background: There is lack of population level data on prevalence and distribution of common benign women's health conditions such as endometriosis, uterine fibroids, polycystic ovary syndrome from the Eastern Mediterranean region despite their significant consequences on quality of life. In particular, there is complete absence of any health statistics from Northern Cyprus, which is an emerging region in Europe. The Cyprus Women's Health Research (COHERE) Initiative is the first large-scale cross-sectional study in the region, aiming to determine the relative burden of benign women's health conditions and related co-morbidities in women living in Northern Cyprus. Methods: The COHERE Initiative is a cross-sectional study aiming to recruit 8000 women aged 18 55 years and residing for at least the past 5 years in Northern Cyprus. The study is composed of two main steps: (1) Baseline recruitment, including (i) completion of a detailed health questionnaire, which is an expanded version of the World Endometriosis Research Foundation (WERF) Endometriosis Phenome Harmonisation Project (EPHect) standardised questionnaire, including questions on demographics, menstrual history, hormone use, pregnancy, pain (pelvic pain, bladder and bowel pain, migraine), medical history, family history of illnesses, medication use, life-style factors in relation to a wide range of reproductive and endocrine conditions, resource use (ii) measurement of weight, height, waist/hip circumference and blood pressure, (iii) collection of saliva samples for genotyping. (2) Gynaecology clinic follow up, including a pelvic ultrasound scan (USS). There is also a follow-up food frequency questionnaire (FFQ) targeted to all women taking part in the baseline recruitment with an aim to collect more detailed data on dietary habits. Discussion: The COHERE Initiative will generate prevalence rates for conditions, define the clinical profiles for women's health conditions, and estimate the economic burden of these conditions in Northern Cyprus. The results will also provide insights into the current status of health-care among women living in a currently under-investigated region. The genetic findings will inform future gene mapping studies for investigation of the heritable component of conditions in this population/region. Moreover, the results will be compared with other centres collecting data using EPHect tools globally and will help determine population differences and similarities in disease patterns and clinical profiles. The COHERE Initiative will serve as a resource to conduct hypothesis-driven follow-up studies investigating effect of the Mediterranean life-style' as well as genetic factors on common benign women's health conditions that maybe specific to Eastern Mediterranean populations.

Original languageEnglish
Article number50
JournalBMC Women's Health
Volume19
Issue number1
Number of pages7
ISSN1745-5057
DOIs
Publication statusPublished - 2019

Keywords

  • Benign women's health conditions
  • Chronic pain conditions
  • Eastern Mediterranean population
  • Endometriosis
  • PCOS
  • Prevalence
  • Uterine fibroids

Cite this

Hocaoglu, M. B. ; Gurkas, S. ; Karaderi, T. ; Taneri, B. ; Erguler, K. ; Barin, B. ; Bilgin, E. M. ; Eralp, G. ; Allison, M. ; Findikli, N. ; Boynukalin, K. ; Bahceci, M. ; Naci, H. ; Vincent, K. ; Missmer, S. A. ; Becker, C. M. ; Zondervan, K. T. ; Rahmioglu, N. / Cyprus Women's Health Research (COHERE) initiative : Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population. In: BMC Women's Health. 2019 ; Vol. 19, No. 1.
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title = "Cyprus Women's Health Research (COHERE) initiative: Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population",
abstract = "Background: There is lack of population level data on prevalence and distribution of common benign women's health conditions such as endometriosis, uterine fibroids, polycystic ovary syndrome from the Eastern Mediterranean region despite their significant consequences on quality of life. In particular, there is complete absence of any health statistics from Northern Cyprus, which is an emerging region in Europe. The Cyprus Women's Health Research (COHERE) Initiative is the first large-scale cross-sectional study in the region, aiming to determine the relative burden of benign women's health conditions and related co-morbidities in women living in Northern Cyprus. Methods: The COHERE Initiative is a cross-sectional study aiming to recruit 8000 women aged 18 55 years and residing for at least the past 5 years in Northern Cyprus. The study is composed of two main steps: (1) Baseline recruitment, including (i) completion of a detailed health questionnaire, which is an expanded version of the World Endometriosis Research Foundation (WERF) Endometriosis Phenome Harmonisation Project (EPHect) standardised questionnaire, including questions on demographics, menstrual history, hormone use, pregnancy, pain (pelvic pain, bladder and bowel pain, migraine), medical history, family history of illnesses, medication use, life-style factors in relation to a wide range of reproductive and endocrine conditions, resource use (ii) measurement of weight, height, waist/hip circumference and blood pressure, (iii) collection of saliva samples for genotyping. (2) Gynaecology clinic follow up, including a pelvic ultrasound scan (USS). There is also a follow-up food frequency questionnaire (FFQ) targeted to all women taking part in the baseline recruitment with an aim to collect more detailed data on dietary habits. Discussion: The COHERE Initiative will generate prevalence rates for conditions, define the clinical profiles for women's health conditions, and estimate the economic burden of these conditions in Northern Cyprus. The results will also provide insights into the current status of health-care among women living in a currently under-investigated region. The genetic findings will inform future gene mapping studies for investigation of the heritable component of conditions in this population/region. Moreover, the results will be compared with other centres collecting data using EPHect tools globally and will help determine population differences and similarities in disease patterns and clinical profiles. The COHERE Initiative will serve as a resource to conduct hypothesis-driven follow-up studies investigating effect of the Mediterranean life-style' as well as genetic factors on common benign women's health conditions that maybe specific to Eastern Mediterranean populations.",
keywords = "Benign women's health conditions, Chronic pain conditions, Eastern Mediterranean population, Endometriosis, PCOS, Prevalence, Uterine fibroids",
author = "Hocaoglu, {M. B.} and S. Gurkas and T. Karaderi and B. Taneri and K. Erguler and B. Barin and Bilgin, {E. M.} and G. Eralp and M. Allison and N. Findikli and K. Boynukalin and M. Bahceci and H. Naci and K. Vincent and Missmer, {S. A.} and Becker, {C. M.} and Zondervan, {K. T.} and N. Rahmioglu",
year = "2019",
doi = "10.1186/s12905-019-0750-1",
language = "English",
volume = "19",
journal = "Women's Health",
issn = "1745-5057",
publisher = "Future Medicine Ltd.",
number = "1",

}

Hocaoglu, MB, Gurkas, S, Karaderi, T, Taneri, B, Erguler, K, Barin, B, Bilgin, EM, Eralp, G, Allison, M, Findikli, N, Boynukalin, K, Bahceci, M, Naci, H, Vincent, K, Missmer, SA, Becker, CM, Zondervan, KT & Rahmioglu, N 2019, 'Cyprus Women's Health Research (COHERE) initiative: Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population', BMC Women's Health, vol. 19, no. 1, 50. https://doi.org/10.1186/s12905-019-0750-1

Cyprus Women's Health Research (COHERE) initiative : Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population. / Hocaoglu, M. B.; Gurkas, S.; Karaderi, T.; Taneri, B.; Erguler, K.; Barin, B.; Bilgin, E. M.; Eralp, G.; Allison, M.; Findikli, N.; Boynukalin, K.; Bahceci, M.; Naci, H.; Vincent, K.; Missmer, S. A.; Becker, C. M.; Zondervan, K. T.; Rahmioglu, N.

In: BMC Women's Health, Vol. 19, No. 1, 50, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Cyprus Women's Health Research (COHERE) initiative

T2 - Determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population

AU - Hocaoglu, M. B.

AU - Gurkas, S.

AU - Karaderi, T.

AU - Taneri, B.

AU - Erguler, K.

AU - Barin, B.

AU - Bilgin, E. M.

AU - Eralp, G.

AU - Allison, M.

AU - Findikli, N.

AU - Boynukalin, K.

AU - Bahceci, M.

AU - Naci, H.

AU - Vincent, K.

AU - Missmer, S. A.

AU - Becker, C. M.

AU - Zondervan, K. T.

AU - Rahmioglu, N.

PY - 2019

Y1 - 2019

N2 - Background: There is lack of population level data on prevalence and distribution of common benign women's health conditions such as endometriosis, uterine fibroids, polycystic ovary syndrome from the Eastern Mediterranean region despite their significant consequences on quality of life. In particular, there is complete absence of any health statistics from Northern Cyprus, which is an emerging region in Europe. The Cyprus Women's Health Research (COHERE) Initiative is the first large-scale cross-sectional study in the region, aiming to determine the relative burden of benign women's health conditions and related co-morbidities in women living in Northern Cyprus. Methods: The COHERE Initiative is a cross-sectional study aiming to recruit 8000 women aged 18 55 years and residing for at least the past 5 years in Northern Cyprus. The study is composed of two main steps: (1) Baseline recruitment, including (i) completion of a detailed health questionnaire, which is an expanded version of the World Endometriosis Research Foundation (WERF) Endometriosis Phenome Harmonisation Project (EPHect) standardised questionnaire, including questions on demographics, menstrual history, hormone use, pregnancy, pain (pelvic pain, bladder and bowel pain, migraine), medical history, family history of illnesses, medication use, life-style factors in relation to a wide range of reproductive and endocrine conditions, resource use (ii) measurement of weight, height, waist/hip circumference and blood pressure, (iii) collection of saliva samples for genotyping. (2) Gynaecology clinic follow up, including a pelvic ultrasound scan (USS). There is also a follow-up food frequency questionnaire (FFQ) targeted to all women taking part in the baseline recruitment with an aim to collect more detailed data on dietary habits. Discussion: The COHERE Initiative will generate prevalence rates for conditions, define the clinical profiles for women's health conditions, and estimate the economic burden of these conditions in Northern Cyprus. The results will also provide insights into the current status of health-care among women living in a currently under-investigated region. The genetic findings will inform future gene mapping studies for investigation of the heritable component of conditions in this population/region. Moreover, the results will be compared with other centres collecting data using EPHect tools globally and will help determine population differences and similarities in disease patterns and clinical profiles. The COHERE Initiative will serve as a resource to conduct hypothesis-driven follow-up studies investigating effect of the Mediterranean life-style' as well as genetic factors on common benign women's health conditions that maybe specific to Eastern Mediterranean populations.

AB - Background: There is lack of population level data on prevalence and distribution of common benign women's health conditions such as endometriosis, uterine fibroids, polycystic ovary syndrome from the Eastern Mediterranean region despite their significant consequences on quality of life. In particular, there is complete absence of any health statistics from Northern Cyprus, which is an emerging region in Europe. The Cyprus Women's Health Research (COHERE) Initiative is the first large-scale cross-sectional study in the region, aiming to determine the relative burden of benign women's health conditions and related co-morbidities in women living in Northern Cyprus. Methods: The COHERE Initiative is a cross-sectional study aiming to recruit 8000 women aged 18 55 years and residing for at least the past 5 years in Northern Cyprus. The study is composed of two main steps: (1) Baseline recruitment, including (i) completion of a detailed health questionnaire, which is an expanded version of the World Endometriosis Research Foundation (WERF) Endometriosis Phenome Harmonisation Project (EPHect) standardised questionnaire, including questions on demographics, menstrual history, hormone use, pregnancy, pain (pelvic pain, bladder and bowel pain, migraine), medical history, family history of illnesses, medication use, life-style factors in relation to a wide range of reproductive and endocrine conditions, resource use (ii) measurement of weight, height, waist/hip circumference and blood pressure, (iii) collection of saliva samples for genotyping. (2) Gynaecology clinic follow up, including a pelvic ultrasound scan (USS). There is also a follow-up food frequency questionnaire (FFQ) targeted to all women taking part in the baseline recruitment with an aim to collect more detailed data on dietary habits. Discussion: The COHERE Initiative will generate prevalence rates for conditions, define the clinical profiles for women's health conditions, and estimate the economic burden of these conditions in Northern Cyprus. The results will also provide insights into the current status of health-care among women living in a currently under-investigated region. The genetic findings will inform future gene mapping studies for investigation of the heritable component of conditions in this population/region. Moreover, the results will be compared with other centres collecting data using EPHect tools globally and will help determine population differences and similarities in disease patterns and clinical profiles. The COHERE Initiative will serve as a resource to conduct hypothesis-driven follow-up studies investigating effect of the Mediterranean life-style' as well as genetic factors on common benign women's health conditions that maybe specific to Eastern Mediterranean populations.

KW - Benign women's health conditions

KW - Chronic pain conditions

KW - Eastern Mediterranean population

KW - Endometriosis

KW - PCOS

KW - Prevalence

KW - Uterine fibroids

U2 - 10.1186/s12905-019-0750-1

DO - 10.1186/s12905-019-0750-1

M3 - Journal article

VL - 19

JO - Women's Health

JF - Women's Health

SN - 1745-5057

IS - 1

M1 - 50

ER -