Cyclic Citrullinated Peptide Aptamer Treatment Attenuates Collagen-Induced Arthritis

Sangita Khatri, Jonas Hansen, Nadia Bom Pedersen, Idamarie Palsbom Brandt-Clausen, Sanne Gram-Nielsen, Ana C. Mendes, Ioannis S. Chronakis, Ulrik Bering Keiding, Anca I. Catrina, Bence Rethi, Mads Hartvig Clausen, Tue Kragstrup, Kira Astakhova*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


We describe the study of a novel aptamer-based candidate for treatment of seropositive rheumatoid arthritis. The candidate is a nanoparticle-formulated cyclic citrullinated peptide aptamer, which targets autoantibodies and/or the immune reactions leading to antibody production. Due to its specificity, the peptide aptamer nanoparticles might not interfere with normal immune functions as seen with other disease-modifying antirheumatic drugs. Over a 3-week course of treatment, joint swelling and arthritis score in collagen-induced rats were significantly decreased compared with animals treated with phosphate-buffered saline, unloaded nanoparticles, or nanoparticles with a noncitrullinated control peptide. The reduction in joint swelling was associated with decreased anticitrullinated peptide autoantibody levels in the blood. Treatment with aptamer nanoparticles also increased interleukin-10 levels. The effect seen with the proposed treatment candidate could be mediated by upregulation of anti-inflammatory mediators and decreased levels of anticitrullinated peptide antibodies.
Original languageEnglish
Issue number5
Pages (from-to)2126-2137
Number of pages12
Publication statusPublished - 2022


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