Cu-Mediated Stille Reactions of Sterically Congested Fragments: Towards the Total Synthesis of Zoanthamine

Thomas E. Nielsen, Sebastian Le Quement, Martin Juhl, David Ackland Tanner

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A study on the Stille reaction of alkenyl iodides and starmanes with structural resemblance to retrosynthetic fragments of a projected total synthesis of the marine alkaloid zoanthamine was carried out. A range of reaction conditions was examined, and a protocol developed by Corey utilizing excess copper(I) chloride and lithium chloride was found to be most efficient. The methodology was successfully applied to join two major fragments of the zoanthamine skeleton. (c) 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
JournalTetrahedron
Volume61
Issue number33
Pages (from-to)8013 - 8024
ISSN0040-4020
DOIs
Publication statusPublished - 2005

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