CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

Thea S. B. Kjeldsen; Martin Overgaard; Søren S. Nielsen; Valeria Bortolaia; Lotte Jelsbak; Morten Otto Alexander Sommer; Luca Guardabassi; John E. Olsen

doi:10.1093/jac/dku332

CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

Thea S. B. Kjeldsen
, Martin Overgaard
, Søren S. Nielsen
, Valeria Bortolaia
, Lotte Jelsbak
, Morten Otto Alexander Sommer
, Luca Guardabassi
, John E. Olsen

University of Copenhagen
Odense University Hospital

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.

Original language	English
Journal	Journal of Antimicrobial Chemotherapy
Volume	70
Issue number	1
Pages (from-to)	62-70
ISSN	0305-7453
DOIs	https://doi.org/10.1093/jac/dku332
Publication status	Published - 2015

Keywords

Antimicrobial resistance
ESBLs
Regulation

Access to Document

10.1093/jac/dku332

OpenUrl availability

Check availability in DTU Findit

Cite this

@article{2c512e91f77c472facc0c8a8b995e340,

title = "CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.",

abstract = "blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.",

keywords = "Antimicrobial resistance, ESBLs, Regulation",

author = "Kjeldsen, \{Thea S. B.\} and Martin Overgaard and Nielsen, \{S{\o}ren S.\} and Valeria Bortolaia and Lotte Jelsbak and Sommer, \{Morten Otto Alexander\} and Luca Guardabassi and Olsen, \{John E.\}",

year = "2015",

doi = "10.1093/jac/dku332",

language = "English",

volume = "70",

pages = "62--70",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

AU - Kjeldsen, Thea S. B.

AU - Overgaard, Martin

AU - Nielsen, Søren S.

AU - Bortolaia, Valeria

AU - Jelsbak, Lotte

AU - Sommer, Morten Otto Alexander

AU - Guardabassi, Luca

AU - Olsen, John E.

PY - 2015

Y1 - 2015

N2 - blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.

AB - blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.

KW - Antimicrobial resistance

KW - ESBLs

KW - Regulation

U2 - 10.1093/jac/dku332

DO - 10.1093/jac/dku332

M3 - Journal article

C2 - 25182062

SN - 0305-7453

VL - 70

SP - 62

EP - 70

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -

CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this