CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

Thea S. B. Kjeldsen, Martin Overgaard, Søren S. Nielsen, Valeria Bortolaia, Lotte Jelsbak, Morten Otto Alexander Sommer, Luca Guardabassi, John E. Olsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.
Original languageEnglish
JournalJournal of Antimicrobial Chemotherapy
Volume70
Issue number1
Pages (from-to)62-70
ISSN0305-7453
DOIs
Publication statusPublished - 2015

Keywords

  • Antimicrobial resistance
  • ESBLs
  • Regulation

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