blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.
- Antimicrobial resistance
Kjeldsen, T. S. B., Overgaard, M., Nielsen, S. S., Bortolaia, V., Jelsbak, L., Sommer, M. O. A., Guardabassi, L., & Olsen, J. E. (2015). CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location. Journal of Antimicrobial Chemotherapy, 70(1), 62-70. https://doi.org/10.1093/jac/dku332