Abstract
A crystalline form of dopamine β-hydroxylase is provided. X-ray crystallography reveals the space group and cell dimensions, as well as the atomic coordinates. The information can be used for identifying one or more modulators of dopamine β-hydroxylase, which can then be chemically synthesised and used in treatment. A process for preparing the crystalline form of human dopamine β-hydroxylase is also provided.
| Original language | English |
|---|---|
| IPC | C12N 9/ 02 A I |
| Patent number | WO2017174762 |
| Filing date | 12/10/2017 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 07/04/2016 |
| Priority number | EP20160164227 |
| Publication status | Published - 12 Oct 2017 |